Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1351724..1352344 Replicon chromosome
Accession NZ_CP102827
Organism Salmonella enterica subsp. enterica serovar Indiana strain XZ14C1328

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NV345_RS06390 Protein ID WP_001280991.1
Coordinates 1351724..1351942 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NV345_RS06395 Protein ID WP_000344807.1
Coordinates 1351970..1352344 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV345_RS06350 (1346947) 1346947..1347516 + 570 WP_000779802.1 YbaY family lipoprotein -
NV345_RS06355 (1347549) 1347549..1347938 - 390 WP_000961285.1 MGMT family protein -
NV345_RS06365 (1348169) 1348169..1349719 - 1551 WP_023210786.1 EAL domain-containing protein -
NV345_RS06370 (1349944) 1349944..1350204 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NV345_RS06375 (1350210) 1350210..1350350 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NV345_RS06380 (1350406) 1350406..1350876 - 471 WP_000136181.1 YlaC family protein -
NV345_RS06385 (1350994) 1350994..1351545 - 552 WP_001278793.1 maltose O-acetyltransferase -
NV345_RS06390 (1351724) 1351724..1351942 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NV345_RS06395 (1351970) 1351970..1352344 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NV345_RS06400 (1352840) 1352840..1355989 - 3150 WP_051129102.1 efflux RND transporter permease AcrB -
NV345_RS06405 (1356012) 1356012..1357205 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T254206 WP_001280991.1 NZ_CP102827:c1351942-1351724 [Salmonella enterica subsp. enterica serovar Indiana]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT254206 WP_000344807.1 NZ_CP102827:c1352344-1351970 [Salmonella enterica subsp. enterica serovar Indiana]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References