Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 616558..617074 Replicon chromosome
Accession NZ_CP102827
Organism Salmonella enterica subsp. enterica serovar Indiana strain XZ14C1328

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag NV345_RS02875 Protein ID WP_000220577.1
Coordinates 616790..617074 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NV345_RS02870 Protein ID WP_000212724.1
Coordinates 616558..616800 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV345_RS02850 (611578) 611578..612711 + 1134 WP_023226979.1 amidohydrolase/deacetylase family metallohydrolase -
NV345_RS02855 (612695) 612695..613813 + 1119 WP_023137277.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NV345_RS02860 (613810) 613810..614550 + 741 WP_000779254.1 KDGP aldolase family protein -
NV345_RS02865 (614567) 614567..616480 + 1914 WP_023226980.1 BglG family transcription antiterminator -
NV345_RS02870 (616558) 616558..616800 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NV345_RS02875 (616790) 616790..617074 + 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NV345_RS02880 (617078) 617078..617542 - 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NV345_RS02885 (617759) 617759..619897 - 2139 WP_023226981.1 anaerobic ribonucleoside-triphosphate reductase -
NV345_RS02890 (620306) 620306..621958 - 1653 WP_000155050.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T254203 WP_000220577.1 NZ_CP102827:616790-617074 [Salmonella enterica subsp. enterica serovar Indiana]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT254203 WP_000212724.1 NZ_CP102827:616558-616800 [Salmonella enterica subsp. enterica serovar Indiana]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References