Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 5947691..5948214 Replicon chromosome
Accession NZ_CP102826
Organism Saccharopolyspora rosea strain A22

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NV263_RS27610 Protein ID WP_263249648.1
Coordinates 5947954..5948214 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NV263_RS27605 Protein ID WP_263249646.1
Coordinates 5947691..5947957 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV263_RS27595 5945043..5946668 - 1626 WP_263249643.1 DNA polymerase Y family protein -
NV263_RS27600 5946674..5947396 - 723 WP_263249645.1 hypothetical protein -
NV263_RS27605 5947691..5947957 + 267 WP_263249646.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NV263_RS27610 5947954..5948214 + 261 WP_263249648.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NV263_RS27615 5948257..5948532 - 276 WP_263249650.1 DUF4381 family protein -
NV263_RS27620 5948673..5949329 - 657 WP_263249651.1 response regulator transcription factor -
NV263_RS27625 5949326..5950453 - 1128 WP_263249652.1 sensor histidine kinase -
NV263_RS27630 5950552..5952117 - 1566 WP_263249653.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
NV263_RS27635 5952114..5952707 - 594 WP_263249654.1 phosphoribosylglycinamide formyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9200.45 Da        Isoelectric Point: 10.5714

>T254200 WP_263249648.1 NZ_CP102826:5947954-5948214 [Saccharopolyspora rosea]
VSHDVRITACAARDLARLPERTAAACVRFVFGPLADAPTEAGDGLRGEFEGLRSARRGSYRVVYAVRKNDVVVHAIRAAH
RAGAQG

Download         Length: 261 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9591.75 Da        Isoelectric Point: 4.8308

>AT254200 WP_263249646.1 NZ_CP102826:5947691-5947957 [Saccharopolyspora rosea]
MATIPLGDARNRLSEVVVQVQTTHERVVITRHGRPAAVLVAPDDLTALEETLDLLSTPGEAEAVREGVADAASGRFADAD
EIRRRYQR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References