Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1133365..1134038 Replicon chromosome
Accession NZ_CP102826
Organism Saccharopolyspora rosea strain A22

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NV263_RS05565 Protein ID WP_263251474.1
Coordinates 1133604..1134038 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NV263_RS05560 Protein ID WP_263251473.1
Coordinates 1133365..1133607 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV263_RS05545 1128739..1131372 + 2634 WP_263251470.1 valine--tRNA ligase -
NV263_RS05550 1131477..1132844 + 1368 WP_263251471.1 folylpolyglutamate synthase/dihydrofolate synthase family protein -
NV263_RS05555 1132841..1133296 + 456 WP_263251472.1 DUF4233 domain-containing protein -
NV263_RS05560 1133365..1133607 + 243 WP_263251473.1 ribbon-helix-helix protein, CopG family Antitoxin
NV263_RS05565 1133604..1134038 + 435 WP_263251474.1 type II toxin-antitoxin system VapC family toxin Toxin
NV263_RS05570 1134035..1135135 - 1101 WP_263251475.1 zinc-binding dehydrogenase -
NV263_RS05575 1135280..1136823 + 1544 Protein_1082 alkaline phosphatase D family protein -
NV263_RS05580 1136933..1137343 + 411 WP_263251476.1 nucleoside-diphosphate kinase -
NV263_RS05585 1137348..1137893 + 546 WP_263251477.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-32)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 16058.43 Da        Isoelectric Point: 6.3234

>T254199 WP_263251474.1 NZ_CP102826:1133604-1134038 [Saccharopolyspora rosea]
VIACDVNILLNAQNAALPDHERFATWFEDALNGATPVGIPSMVFSGYLRIVTNHRIWPRPLQPEQALEIIAAIRTAPAFA
PIEPGPRHWEIFAELCRKAQVKANLVPDAYLAAIAIEHGCEWITADRGFARYPGVRWRHPLDDG

Download         Length: 435 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9211.45 Da        Isoelectric Point: 5.1457

>AT254199 WP_263251473.1 NZ_CP102826:1133365-1133607 [Saccharopolyspora rosea]
MRTTITIDDQLLERLKLRAAREHTTVSALIEDDVRLGELRRARAQDRPRFKLPTFDLGAPRPGVDLNDNAALLEFMEHDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References