254194

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 3861..4449 Replicon plasmid unnamed4
Accession NZ_CP102819
Organism Acinetobacter baumannii strain AB176-VUB

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag L2Z12_RS19475 Protein ID WP_000438826.1
Coordinates 3861..4148 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag L2Z12_RS19480 Protein ID WP_001983304.1
Coordinates 4135..4449 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z12_RS19450 (L2Z12_19470) 1..951 + 951 WP_001205343.1 replication initiation protein RepM -
L2Z12_RS19455 (L2Z12_19475) 944..1519 + 576 WP_001096616.1 plasmid replication DNA-binding protein -
L2Z12_RS19460 (L2Z12_19480) 1539..1682 + 144 WP_001125246.1 hypothetical protein -
L2Z12_RS19465 (L2Z12_19485) 1865..2692 - 828 WP_000713530.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-72 -
L2Z12_RS19470 (L2Z12_19490) 2844..3590 + 747 WP_005262957.1 IS5-like element ISAba31 family transposase -
L2Z12_RS19475 (L2Z12_19495) 3861..4148 + 288 WP_000438826.1 BrnT family toxin Toxin
L2Z12_RS19480 (L2Z12_19500) 4135..4449 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
L2Z12_RS19485 (L2Z12_19505) 4577..6988 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
L2Z12_RS19490 (L2Z12_19510) 7293..7754 + 462 WP_000761346.1 DIP1984 family protein -
L2Z12_RS19495 (L2Z12_19515) 8077..8250 - 174 WP_001282484.1 hypothetical protein -
L2Z12_RS19500 (L2Z12_19520) 8250..8621 - 372 WP_000504218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-72 - 1..9830 9830
- flank IS/Tn blaOXA-72 - 1865..3590 1725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T254194 WP_000438826.1 NZ_CP102819:3861-4148 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT254194 WP_001983304.1 NZ_CP102819:4135-4449 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References