Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1403591..1405427 Replicon chromosome
Accession NZ_CP102780
Organism Pandoraea commovens strain LB-19-202-79

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NTU39_RS06890 Protein ID WP_257959546.1
Coordinates 1403591..1404499 (+) Length 303 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag NTU39_RS06895 Protein ID WP_174984868.1
Coordinates 1404549..1405427 (+) Length 293 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTU39_RS06865 (NTU39_06865) 1398968..1400044 + 1077 WP_174984871.1 porin -
NTU39_RS06870 (NTU39_06870) 1400357..1401226 + 870 WP_150665179.1 ABC transporter ATP-binding protein -
NTU39_RS06875 (NTU39_06875) 1401271..1402053 + 783 WP_150577656.1 ABC transporter permease -
NTU39_RS06880 (NTU39_06880) 1402108..1402881 + 774 WP_257960054.1 SDR family oxidoreductase -
NTU39_RS06885 (NTU39_06885) 1402922..1403479 + 558 WP_039400236.1 cupin domain-containing protein -
NTU39_RS06890 (NTU39_06890) 1403591..1404499 + 909 WP_257959546.1 alpha/beta fold hydrolase Toxin
NTU39_RS06895 (NTU39_06895) 1404549..1405427 + 879 WP_174984868.1 IclR family transcriptional regulator Antitoxin
NTU39_RS06900 (NTU39_06900) 1405424..1406239 + 816 WP_257959547.1 SDR family oxidoreductase -
NTU39_RS06905 (NTU39_06905) 1406232..1407884 + 1653 WP_257959548.1 thiamine pyrophosphate-binding protein -
NTU39_RS06910 (NTU39_06910) 1407877..1408695 + 819 WP_150577662.1 aspartate dehydrogenase -
NTU39_RS06915 (NTU39_06915) 1408709..1410205 + 1497 WP_257959549.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-288)

Antitoxin

Transcription regulator IclR, C-terminal

(147-270)


Sequences

Toxin        


Download         Length: 303 a.a.        Molecular weight: 31525.75 Da        Isoelectric Point: 6.1512

>T254187 WP_257959546.1 NZ_CP102780:1403591-1404499 [Pandoraea commovens]
MQAEAHQHEVPEDDVVAPLRARLDAFPYRTVATRAGTVGYRCVGTENDAGVPVVMLHGIGSGAASWLAQFEATGLDAKLY
AWDAPGYGATSNVAAAEPHPDAYADALEAWLDTLGLDRVALVGHSLGAIMATKFASRAPQRVRGLFLCSPANGYARADAE
VRLSKRDSRLAMLDKLGPAGMARERSDNLVAPGAADLPRAWVKWNMSRVLPVGYRQATHLLSNGDVAGELAQYVSAKAGP
VAVAVGAQDGITSPAACEVIAKVAGVPLQIIDGAGHASYIETPDVLNAALAAWLERVAAGGR

Download         Length: 909 bp

Antitoxin


Download         Length: 293 a.a.        Molecular weight: 31937.53 Da        Isoelectric Point: 6.7654

>AT254187 WP_174984868.1 NZ_CP102780:1404549-1405427 [Pandoraea commovens]
MHDDQNVSLDGDAVVEGAAESRYLVPGLERGLRILTQFSPREPVFSAPELSQRLGIPRTTVFRLLQTLEAMGFLERAGSE
KNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQSVAGVFNSIKVNVGTRLPAHAT
VHGHVLMGDLTLTELRALYPEKTLEKFTPQTPESLTELFERVREDAERGYAVSASSFERGISVVSAPVRNDVGRICAAIT
VTIPRANIDASMLDAGLIGQVREAADALSHRLNYRPGSDGKSTPYMKSLGLK

Download         Length: 879 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References