Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 127299..127840 Replicon chromosome
Accession NZ_CP102772
Organism Bosea sp. NBC_00550

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NWE53_RS00600 Protein ID WP_265052471.1
Coordinates 127299..127622 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NWE53_RS00605 Protein ID WP_265052472.1
Coordinates 127619..127840 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWE53_RS00580 (NWE53_00580) 123104..124252 + 1149 WP_265052467.1 alpha/beta hydrolase -
NWE53_RS00585 (NWE53_00585) 124385..125389 + 1005 WP_265052468.1 alpha/beta fold hydrolase -
NWE53_RS00590 (NWE53_00590) 125390..125848 - 459 WP_265052469.1 Lrp/AsnC family transcriptional regulator -
NWE53_RS00595 (NWE53_00595) 125991..127274 + 1284 WP_265052470.1 cystathionine gamma-synthase family protein -
NWE53_RS00600 (NWE53_00600) 127299..127622 - 324 WP_265052471.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NWE53_RS00605 (NWE53_00605) 127619..127840 - 222 WP_265052472.1 antitoxin MazE family protein Antitoxin
NWE53_RS00610 (NWE53_00610) 127913..128650 - 738 WP_265055043.1 DUF3750 domain-containing protein -
NWE53_RS00615 (NWE53_00615) 128936..130000 + 1065 WP_265055044.1 polyamine ABC transporter substrate-binding protein -
NWE53_RS00620 (NWE53_00620) 130026..131180 + 1155 WP_265052473.1 ABC transporter ATP-binding protein -
NWE53_RS00625 (NWE53_00625) 131362..132255 + 894 WP_265052474.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(7-69)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11499.61 Da        Isoelectric Point: 10.4471

>T254184 WP_265052471.1 NZ_CP102772:c127622-127299 [Bosea sp. NBC_00550]
MKRGDLVTVALAGDFGKPRPALIVQADPFDLTATVTVLLLSSDLVDAPLIRLTIQPNAANGLRLASQIMVDKAMTVRRDR
IGQIFGRVDPDMMIAVNRSLALFLGLG

Download         Length: 324 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8130.11 Da        Isoelectric Point: 5.8189

>AT254184 WP_265052472.1 NZ_CP102772:c127840-127619 [Bosea sp. NBC_00550]
MAASTARRVQKRREALRAAGLRPIQIWIPDTRQPGFNEECRRQARMAAAADGADHDLDGFIDAALEDLDRAPE

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References