Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1348039..1348955 Replicon chromosome
Accession NZ_CP102769
Organism Bacillus subtilis strain YZSR384

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag NVS73_RS07095 Protein ID WP_003244695.1
Coordinates 1348209..1348955 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag NVS73_RS07090 Protein ID WP_003232646.1
Coordinates 1348039..1348209 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NVS73_RS07055 (1344902) 1344902..1345231 + 330 WP_003232660.1 XkdW family protein -
NVS73_RS07060 (1345228) 1345228..1345392 + 165 WP_003232658.1 XkdX family protein -
NVS73_RS07065 (1345436) 1345436..1346275 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
NVS73_RS07070 (1346328) 1346328..1346597 + 270 WP_003232655.1 hemolysin XhlA family protein -
NVS73_RS07075 (1346610) 1346610..1346873 + 264 WP_003232653.1 phage holin -
NVS73_RS07080 (1346886) 1346886..1347779 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
NVS73_RS07085 (1347816) 1347816..1347953 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
NVS73_RS07090 (1348039) 1348039..1348209 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
NVS73_RS07095 (1348209) 1348209..1348955 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
NVS73_RS07100 (1349065) 1349065..1350066 - 1002 WP_003232642.1 inorganic phosphate transporter -
NVS73_RS07105 (1350079) 1350079..1350696 - 618 WP_003218470.1 DUF47 domain-containing protein -
NVS73_RS07110 (1350972) 1350972..1352288 - 1317 WP_003244819.1 serine/threonine exchanger -
NVS73_RS07115 (1352677) 1352677..1353627 + 951 WP_003245086.1 ring-cleaving dioxygenase -
NVS73_RS07120 (1353728) 1353728..1353874 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T254164 WP_003244695.1 NZ_CP102769:c1348955-1348209 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT254164 WP_003232646.1 NZ_CP102769:c1348209-1348039 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References