Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1971906..1973542 Replicon chromosome
Accession NZ_CP102762
Organism Acinetobacter baumannii strain AOR07-BL

Toxin (Protein)


Gene name hipA Uniprot ID A0A9F1U5K1
Locus tag NU955_RS09460 Protein ID WP_005128640.1
Coordinates 1972211..1973542 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NU955_RS09455 Protein ID WP_001101310.1
Coordinates 1971906..1972214 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU955_RS09430 1967269..1967982 + 714 WP_005128644.1 hypothetical protein -
NU955_RS09435 1967995..1969104 + 1110 WP_005128643.1 XRE family transcriptional regulator -
NU955_RS09440 1969167..1969715 - 549 WP_005128641.1 TetR/AcrR family transcriptional regulator -
NU955_RS09445 1970138..1970647 + 510 WP_230258700.1 helix-turn-helix domain-containing protein -
NU955_RS09450 1970680..1971522 + 843 WP_223673390.1 IS3 family transposase -
NU955_RS09455 1971906..1972214 - 309 WP_001101310.1 helix-turn-helix domain-containing protein Antitoxin
NU955_RS09460 1972211..1973542 - 1332 WP_005128640.1 HipA domain-containing protein Toxin
NU955_RS09465 1973838..1974278 + 441 WP_000193136.1 HD domain-containing protein -
NU955_RS09470 1974313..1974957 - 645 WP_005128638.1 hypothetical protein -
NU955_RS09475 1974969..1975940 - 972 WP_086267245.1 5'/3'-nucleotidase SurE -
NU955_RS09480 1976067..1977245 - 1179 WP_227504097.1 TolC family protein -
NU955_RS09485 1977249..1977815 - 567 Protein_1851 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51189.25 Da        Isoelectric Point: 4.8549

>T254157 WP_005128640.1 NZ_CP102762:c1973542-1972211 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11630.54 Da        Isoelectric Point: 9.9701

>AT254157 WP_001101310.1 NZ_CP102762:c1972214-1971906 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References