Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4708882..4709642 Replicon chromosome
Accession NZ_CP102756
Organism Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS11

Toxin (Protein)


Gene name tacT Uniprot ID A0A5H3Y7E3
Locus tag NWA04_RS22940 Protein ID WP_023225088.1
Coordinates 4708882..4709367 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A3Z2K6C6
Locus tag NWA04_RS22945 Protein ID WP_072106018.1
Coordinates 4709355..4709642 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA04_RS22910 (4703956) 4703956..4704618 + 663 WP_000747548.1 OmpA family lipoprotein -
NWA04_RS22915 (4704837) 4704837..4705811 + 975 WP_023225087.1 glyoxylate/hydroxypyruvate reductase GhrB -
NWA04_RS22920 (4705861) 4705861..4706571 - 711 WP_000190524.1 DUF3053 domain-containing protein -
NWA04_RS22925 (4707010) 4707010..4707300 + 291 WP_000455790.1 HTH-type transcriptional regulator -
NWA04_RS22930 (4707588) 4707588..4707800 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NWA04_RS22935 (4707973) 4707973..4708512 + 540 WP_000047141.1 copper-binding periplasmic metallochaperone CueP -
NWA04_RS22940 (4708882) 4708882..4709367 - 486 WP_023225088.1 GNAT family N-acetyltransferase Toxin
NWA04_RS22945 (4709355) 4709355..4709642 - 288 WP_072106018.1 DUF1778 domain-containing protein Antitoxin
NWA04_RS22950 (4709765) 4709765..4710793 - 1029 WP_023196719.1 HNH endonuclease signature motif containing protein -
NWA04_RS22955 (4711820) 4711820..4712590 + 771 WP_000456879.1 DUF3800 domain-containing protein -
NWA04_RS22960 (4712786) 4712786..4713214 - 429 Protein_4470 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17756.43 Da        Isoelectric Point: 9.0965

>T254156 WP_023225088.1 NZ_CP102756:c4709367-4708882 [Salmonella enterica subsp. enterica serovar Kentucky]
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10982.66 Da        Isoelectric Point: 4.6811

>AT254156 WP_072106018.1 NZ_CP102756:c4709642-4709355 [Salmonella enterica subsp. enterica serovar Kentucky]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H3Y7E3

Antitoxin

Source ID Structure
AlphaFold DB A0A3Z2K6C6

References