Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4708882..4709642 | Replicon | chromosome |
| Accession | NZ_CP102756 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS11 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A5H3Y7E3 |
| Locus tag | NWA04_RS22940 | Protein ID | WP_023225088.1 |
| Coordinates | 4708882..4709367 (-) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | A0A3Z2K6C6 |
| Locus tag | NWA04_RS22945 | Protein ID | WP_072106018.1 |
| Coordinates | 4709355..4709642 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NWA04_RS22910 (4703956) | 4703956..4704618 | + | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
| NWA04_RS22915 (4704837) | 4704837..4705811 | + | 975 | WP_023225087.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| NWA04_RS22920 (4705861) | 4705861..4706571 | - | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| NWA04_RS22925 (4707010) | 4707010..4707300 | + | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| NWA04_RS22930 (4707588) | 4707588..4707800 | + | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| NWA04_RS22935 (4707973) | 4707973..4708512 | + | 540 | WP_000047141.1 | copper-binding periplasmic metallochaperone CueP | - |
| NWA04_RS22940 (4708882) | 4708882..4709367 | - | 486 | WP_023225088.1 | GNAT family N-acetyltransferase | Toxin |
| NWA04_RS22945 (4709355) | 4709355..4709642 | - | 288 | WP_072106018.1 | DUF1778 domain-containing protein | Antitoxin |
| NWA04_RS22950 (4709765) | 4709765..4710793 | - | 1029 | WP_023196719.1 | HNH endonuclease signature motif containing protein | - |
| NWA04_RS22955 (4711820) | 4711820..4712590 | + | 771 | WP_000456879.1 | DUF3800 domain-containing protein | - |
| NWA04_RS22960 (4712786) | 4712786..4713214 | - | 429 | Protein_4470 | IS3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17756.43 Da Isoelectric Point: 9.0965
>T254156 WP_023225088.1 NZ_CP102756:c4709367-4708882 [Salmonella enterica subsp. enterica serovar Kentucky]
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10982.66 Da Isoelectric Point: 4.6811
>AT254156 WP_072106018.1 NZ_CP102756:c4709642-4709355 [Salmonella enterica subsp. enterica serovar Kentucky]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5H3Y7E3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3Z2K6C6 |