254155

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4604819..4605610 Replicon chromosome
Accession NZ_CP102756
Organism Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS11

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag NWA04_RS22480 Protein ID WP_000369560.1
Coordinates 4604819..4605337 (-) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag NWA04_RS22485 Protein ID WP_001275017.1
Coordinates 4605341..4605610 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA04_RS22455 (4599884) 4599884..4600651 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
NWA04_RS22460 (4600648) 4600648..4601925 - 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
NWA04_RS22465 (4601922) 4601922..4602848 - 927 WP_000003005.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NWA04_RS22470 (4602908) 4602908..4604017 - 1110 WP_023224165.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NWA04_RS22475 (4604439) 4604439..4604822 + 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
NWA04_RS22480 (4604819) 4604819..4605337 - 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
NWA04_RS22485 (4605341) 4605341..4605610 - 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
NWA04_RS22490 (4605788) 4605788..4606891 - 1104 WP_001533929.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NWA04_RS22495 (4607213) 4607213..4608067 - 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
NWA04_RS22500 (4608313) 4608313..4609368 - 1056 WP_001081707.1 permease-like cell division protein FtsX -
NWA04_RS22505 (4609361) 4609361..4610029 - 669 WP_000617729.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T254155 WP_000369560.1 NZ_CP102756:c4605337-4604819 [Salmonella enterica subsp. enterica serovar Kentucky]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT254155 WP_001275017.1 NZ_CP102756:c4605610-4605341 [Salmonella enterica subsp. enterica serovar Kentucky]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References