Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3902158..3902972 Replicon chromosome
Accession NZ_CP102756
Organism Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS11

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag NWA04_RS19025 Protein ID WP_000971653.1
Coordinates 3902445..3902972 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NWA04_RS19020 Protein ID WP_000855694.1
Coordinates 3902158..3902448 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA04_RS18990 (3898083) 3898083..3898733 - 651 WP_072203970.1 type III secretion system transcriptional activator InvF -
NWA04_RS18995 (3899191) 3899191..3899634 + 444 WP_023225039.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NWA04_RS19000 (3900066) 3900066..3900515 + 450 WP_023225038.1 hypothetical protein -
NWA04_RS19005 (3900500) 3900500..3900847 + 348 WP_001555786.1 DUF1493 family protein -
NWA04_RS19010 (3901120) 3901120..3901446 - 327 WP_000393295.1 hypothetical protein -
NWA04_RS19015 (3901687) 3901687..3901887 + 201 Protein_3699 transposase -
NWA04_RS19020 (3902158) 3902158..3902448 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NWA04_RS19025 (3902445) 3902445..3902972 + 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
NWA04_RS19030 (3903045) 3903045..3903247 - 203 Protein_3702 IS5/IS1182 family transposase -
NWA04_RS19035 (3903597) 3903597..3904253 + 657 WP_023225036.1 protein-serine/threonine phosphatase -
NWA04_RS19040 (3904425) 3904425..3904919 - 495 WP_000424946.1 hypothetical protein -
NWA04_RS19045 (3904946) 3904946..3905614 - 669 WP_000445914.1 hypothetical protein -
NWA04_RS19050 (3905771) 3905771..3905989 - 219 Protein_3706 hypothetical protein -
NWA04_RS19055 (3906200) 3906200..3906598 - 399 Protein_3707 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3901687..3903221 1534


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T254153 WP_000971653.1 NZ_CP102756:3902445-3902972 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT254153 WP_000855694.1 NZ_CP102756:3902158-3902448 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References