254148

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2473363..2473885 Replicon chromosome
Accession NZ_CP102756
Organism Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS11

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag NWA04_RS11985 Protein ID WP_000221345.1
Coordinates 2473363..2473647 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NWA04_RS11990 Protein ID WP_000885424.1
Coordinates 2473637..2473885 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA04_RS11965 (2469438) 2469438..2470946 - 1509 WP_023223898.1 FAD-dependent oxidoreductase -
NWA04_RS11970 (2470991) 2470991..2471479 + 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
NWA04_RS11975 (2471672) 2471672..2472751 + 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NWA04_RS11980 (2472803) 2472803..2473192 - 390 WP_000194089.1 RidA family protein -
NWA04_RS11985 (2473363) 2473363..2473647 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWA04_RS11990 (2473637) 2473637..2473885 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NWA04_RS11995 (2474037) 2474037..2474156 + 120 Protein_2329 type II and III secretion system -
NWA04_RS12000 (2474242) 2474242..2474573 + 332 Protein_2330 DUF1493 family protein -
NWA04_RS12005 (2474846) 2474846..2475754 + 909 WP_077906523.1 hypothetical protein -
NWA04_RS12010 (2475756) 2475756..2476495 - 740 Protein_2332 hypothetical protein -
NWA04_RS12015 (2476727) 2476727..2476993 - 267 WP_171847526.1 hypothetical protein -
NWA04_RS12020 (2477186) 2477186..2477374 - 189 WP_003033726.1 hypothetical protein -
NWA04_RS12025 (2477498) 2477498..2478613 + 1116 WP_058670966.1 phage/plasmid replication protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T254148 WP_000221345.1 NZ_CP102756:c2473647-2473363 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT254148 WP_000885424.1 NZ_CP102756:c2473885-2473637 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References