Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1480215..1480835 Replicon chromosome
Accession NZ_CP102756
Organism Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS11

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NWA04_RS07080 Protein ID WP_001280991.1
Coordinates 1480215..1480433 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NWA04_RS07085 Protein ID WP_000344807.1
Coordinates 1480461..1480835 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA04_RS07040 (1475438) 1475438..1476007 + 570 WP_000779802.1 YbaY family lipoprotein -
NWA04_RS07045 (1476040) 1476040..1476429 - 390 WP_023224410.1 MGMT family protein -
NWA04_RS07055 (1476660) 1476660..1478210 - 1551 WP_000213145.1 EAL domain-containing protein -
NWA04_RS07060 (1478435) 1478435..1478695 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NWA04_RS07065 (1478701) 1478701..1478841 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NWA04_RS07070 (1478897) 1478897..1479367 - 471 WP_000136183.1 YlaC family protein -
NWA04_RS07075 (1479485) 1479485..1480036 - 552 WP_001278793.1 maltose O-acetyltransferase -
NWA04_RS07080 (1480215) 1480215..1480433 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NWA04_RS07085 (1480461) 1480461..1480835 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NWA04_RS07090 (1481331) 1481331..1484480 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NWA04_RS07095 (1484503) 1484503..1485696 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T254147 WP_001280991.1 NZ_CP102756:c1480433-1480215 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT254147 WP_000344807.1 NZ_CP102756:c1480835-1480461 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References