Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 894122..895745 | Replicon | chromosome |
| Accession | NZ_CP102756 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS11 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | H9TH67 |
| Locus tag | NWA04_RS04280 | Protein ID | WP_000088046.1 |
| Coordinates | 894122..895447 (-) | Length | 442 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
| Locus tag | NWA04_RS04285 | Protein ID | WP_024136327.1 |
| Coordinates | 895452..895745 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NWA04_RS04245 (889391) | 889391..889564 | - | 174 | WP_224435200.1 | hypothetical protein | - |
| NWA04_RS04250 (889660) | 889660..891195 | - | 1536 | WP_001000406.1 | IS66 family transposase | - |
| NWA04_RS04255 (891245) | 891245..891592 | - | 348 | WP_000609174.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| NWA04_RS04260 (892052) | 892052..892261 | - | 210 | WP_223533973.1 | hypothetical protein | - |
| NWA04_RS04265 (892515) | 892515..893330 | - | 816 | WP_001572439.1 | HNH endonuclease signature motif containing protein | - |
| NWA04_RS04270 (893343) | 893343..893753 | - | 411 | WP_000985911.1 | hypothetical protein | - |
| NWA04_RS04275 (893855) | 893855..894061 | - | 207 | WP_000134171.1 | hypothetical protein | - |
| NWA04_RS04280 (894122) | 894122..895447 | - | 1326 | WP_000088046.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| NWA04_RS04285 (895452) | 895452..895745 | - | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| NWA04_RS04290 (896349) | 896349..896741 | - | 393 | WP_000341066.1 | hypothetical protein | - |
| NWA04_RS04295 (897114) | 897114..897449 | + | 336 | WP_065311125.1 | hypothetical protein | - |
| NWA04_RS04300 (897488) | 897488..898285 | - | 798 | WP_000544828.1 | IS21-like element IS21 family helper ATPase IstB | - |
| NWA04_RS04305 (898285) | 898285..899457 | - | 1173 | WP_000952349.1 | IS21-like element IS21 family transposase | - |
| NWA04_RS04310 (899523) | 899523..899978 | + | 456 | WP_224435199.1 | hypothetical protein | - |
| NWA04_RS04315 (900044) | 900044..900325 | + | 282 | WP_000710431.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | aph(3')-Ia / dfrA14 / ARR-3 / mph(A) / ant(3'')-Ia / lnu(F) / aac(3)-IId / blaTEM-1B / rmtB / blaCTX-M-55 / floR | - | 884014..951580 | 67566 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50249.20 Da Isoelectric Point: 6.1927
>T254144 WP_000088046.1 NZ_CP102756:c895447-894122 [Salmonella enterica subsp. enterica serovar Kentucky]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10946.35 Da Isoelectric Point: 10.0925
>AT254144 WP_024136327.1 NZ_CP102756:c895745-895452 [Salmonella enterica subsp. enterica serovar Kentucky]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3T0VBU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Z6V2D1 |