Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 680667..681310 Replicon chromosome
Accession NZ_CP102756
Organism Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS11

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag NWA04_RS03280 Protein ID WP_000048134.1
Coordinates 680667..681083 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag NWA04_RS03285 Protein ID WP_001261294.1
Coordinates 681080..681310 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA04_RS03260 (675704) 675704..676837 + 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -
NWA04_RS03265 (676821) 676821..677939 + 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NWA04_RS03270 (677936) 677936..678676 + 741 WP_000779255.1 KDGP aldolase family protein -
NWA04_RS03275 (678693) 678693..680606 + 1914 WP_001212148.1 BglG family transcription antiterminator -
NWA04_RS03280 (680667) 680667..681083 - 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
NWA04_RS03285 (681080) 681080..681310 - 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NWA04_RS03290 (681478) 681478..681942 - 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NWA04_RS03295 (682159) 682159..684297 - 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T254143 WP_000048134.1 NZ_CP102756:c681083-680667 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT254143 WP_001261294.1 NZ_CP102756:c681310-681080 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References