Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1425975..1426600 Replicon chromosome
Accession NZ_CP102749
Organism Pectobacterium parvum strain YT22221

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag NV347_RS06300 Protein ID WP_005976087.1
Coordinates 1425975..1426178 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A6P1S9D7
Locus tag NV347_RS06305 Protein ID WP_039487867.1
Coordinates 1426232..1426600 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV347_RS06270 (NV347_06270) 1421431..1421769 + 339 WP_039485501.1 P-II family nitrogen regulator -
NV347_RS06275 (NV347_06275) 1421809..1423095 + 1287 WP_039485503.1 ammonium transporter AmtB -
NV347_RS06280 (NV347_06280) 1423231..1424094 - 864 WP_039485505.1 acyl-CoA thioesterase II -
NV347_RS06285 (NV347_06285) 1424306..1424887 + 582 WP_039485508.1 YbaY family lipoprotein -
NV347_RS06290 (NV347_06290) 1424907..1425227 - 321 WP_010282239.1 MGMT family protein -
NV347_RS06300 (NV347_06300) 1425975..1426178 - 204 WP_005976087.1 HHA domain-containing protein Toxin
NV347_RS06305 (NV347_06305) 1426232..1426600 - 369 WP_039487867.1 Hha toxicity modulator TomB Antitoxin
NV347_RS06310 (NV347_06310) 1427198..1427341 - 144 WP_072012464.1 type B 50S ribosomal protein L36 -
NV347_RS06315 (NV347_06315) 1427359..1427607 - 249 WP_015839361.1 type B 50S ribosomal protein L31 -
NV347_RS06320 (NV347_06320) 1427794..1430922 - 3129 WP_039487869.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T254131 WP_005976087.1 NZ_CP102749:c1426178-1425975 [Pectobacterium parvum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14013.72 Da        Isoelectric Point: 4.4776

>AT254131 WP_039487867.1 NZ_CP102749:c1426600-1426232 [Pectobacterium parvum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRHWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1S9D7

References