Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 648900..649453 Replicon chromosome
Accession NZ_CP102749
Organism Pectobacterium parvum strain YT22221

Toxin (Protein)


Gene name relE Uniprot ID A0A6P1S0I2
Locus tag NV347_RS02820 Protein ID WP_039484573.1
Coordinates 649178..649453 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6P1S4N1
Locus tag NV347_RS02815 Protein ID WP_039484576.1
Coordinates 648900..649178 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV347_RS02790 (NV347_02790) 644281..645405 - 1125 WP_039484581.1 polysaccharide lyase -
NV347_RS02795 (NV347_02795) 646257..646508 + 252 WP_039484579.1 hypothetical protein -
NV347_RS02800 (NV347_02800) 647068..647361 + 294 WP_072012385.1 2Fe-2S iron-sulfur cluster-binding protein -
NV347_RS02805 (NV347_02805) 647374..648048 + 675 WP_039512666.1 hypothetical protein -
NV347_RS02810 (NV347_02810) 648534..648668 + 135 Protein_545 recombinase family protein -
NV347_RS02815 (NV347_02815) 648900..649178 + 279 WP_039484576.1 ribbon-helix-helix domain-containing protein Antitoxin
NV347_RS02820 (NV347_02820) 649178..649453 + 276 WP_039484573.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NV347_RS02825 (NV347_02825) 649532..649630 + 99 Protein_548 IS6 family transposase -
NV347_RS02830 (NV347_02830) 649666..649944 - 279 Protein_549 Tn3 family transposase -
NV347_RS02835 (NV347_02835) 649945..650171 + 227 Protein_550 helix-turn-helix domain-containing protein -
NV347_RS02840 (NV347_02840) 650617..650697 - 81 Protein_551 IS1 family transposase -
NV347_RS02845 (NV347_02845) 652012..652587 + 576 WP_014916837.1 aminodeoxychorismate synthase component II -
NV347_RS02850 (NV347_02850) 652707..653933 + 1227 WP_039484568.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 649666..649857 191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10682.30 Da        Isoelectric Point: 7.3183

>T254128 WP_039484573.1 NZ_CP102749:649178-649453 [Pectobacterium parvum]
MEIKWTSKALSDLAHLYEFLALANKSAAARAVQELTQAPAILLTNSRLGEQLFQFEPREIRRFLVGEYEVRHEIEKSVIY
VLRIWHAREDR

Download         Length: 276 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10278.70 Da        Isoelectric Point: 5.6845

>AT254128 WP_039484576.1 NZ_CP102749:648900-649178 [Pectobacterium parvum]
MKNDTQVVTRVLTAHVPLPIADKVDQIAARLERSRGWIMKQALSAWIAQEEERDRLTQEALADVDAGRVIDHQAVQAWAD
SLGTDKPLPVPR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1S0I2

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1S4N1

References