254120

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 942951..943443 Replicon chromosome
Accession NZ_CP102748
Organism Streptococcus suis strain Transconjugant cSFJ45

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag NWE21_RS04700 Protein ID WP_011922404.1
Coordinates 942951..943208 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag NWE21_RS04705 Protein ID WP_012775104.1
Coordinates 943192..943443 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWE21_RS04680 (NWE21_04690) 938585..939655 + 1071 WP_012775436.1 tyrosine recombinase XerS -
NWE21_RS04685 (NWE21_04695) 939725..941233 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
NWE21_RS04690 (NWE21_04700) 941309..942250 - 942 WP_012775102.1 sensor histidine kinase -
NWE21_RS04695 (NWE21_04705) 942247..942912 - 666 WP_012775103.1 response regulator transcription factor -
NWE21_RS04700 (NWE21_04710) 942951..943208 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWE21_RS04705 (NWE21_04715) 943192..943443 - 252 WP_012775104.1 DUF6290 family protein Antitoxin
NWE21_RS04710 (NWE21_04720) 943535..945505 - 1971 WP_012775105.1 FtsX-like permease family protein -
NWE21_RS04715 (NWE21_04725) 945506..946258 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
NWE21_RS04720 (NWE21_04730) 946394..947128 - 735 WP_011922410.1 ABC transporter permease -
NWE21_RS04725 (NWE21_04735) 947130..947876 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T254120 WP_011922404.1 NZ_CP102748:c943208-942951 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT254120 WP_012775104.1 NZ_CP102748:c943443-943192 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References