254119

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 680699..681185 Replicon chromosome
Accession NZ_CP102748
Organism Streptococcus suis strain Transconjugant cSFJ45

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag NWE21_RS03485 Protein ID WP_011922754.1
Coordinates 680916..681185 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag NWE21_RS03480 Protein ID WP_002938604.1
Coordinates 680699..680926 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWE21_RS03455 (NWE21_03460) 675742..676191 - 450 WP_009909619.1 MarR family transcriptional regulator -
NWE21_RS03460 (NWE21_03465) 676485..677332 + 848 WP_087892711.1 IS630 family transposase -
NWE21_RS03465 (NWE21_03470) 677391..677888 + 498 WP_011922751.1 DUF5590 domain-containing protein -
NWE21_RS03470 (NWE21_03475) 677885..679066 + 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
NWE21_RS03475 (NWE21_03480) 679081..680427 + 1347 WP_011922752.1 asparagine--tRNA ligase -
NWE21_RS03480 (NWE21_03485) 680699..680926 + 228 WP_002938604.1 DUF6290 family protein Antitoxin
NWE21_RS03485 (NWE21_03490) 680916..681185 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWE21_RS03490 (NWE21_03495) 681591..682910 + 1320 WP_012775027.1 MATE family efflux transporter -
NWE21_RS03495 (NWE21_03500) 682961..683338 + 378 WP_002937263.1 RidA family protein -
NWE21_RS03500 (NWE21_03505) 683360..684247 + 888 WP_011922160.1 RNase adapter RapZ -
NWE21_RS03505 (NWE21_03510) 684244..685218 + 975 WP_002937257.1 YvcK family protein -
NWE21_RS03510 (NWE21_03515) 685215..686132 + 918 WP_002937252.1 DNA-binding protein WhiA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T254119 WP_011922754.1 NZ_CP102748:680916-681185 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT254119 WP_002938604.1 NZ_CP102748:680699-680926 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References