Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1454822..1455491 Replicon chromosome
Accession NZ_CP102747
Organism Streptococcus parasuis strain SFJ45

Toxin (Protein)


Gene name hicA Uniprot ID G7SGM1
Locus tag NWE22_RS07420 Protein ID WP_014637653.1
Coordinates 1455309..1455491 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NWE22_RS07415 Protein ID WP_239604090.1
Coordinates 1454822..1455271 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWE22_RS07400 (NWE22_07400) 1449953..1452415 - 2463 WP_277745330.1 heavy metal translocating P-type ATPase -
NWE22_RS07405 (NWE22_07405) 1452510..1453367 - 858 WP_277745331.1 SAM-dependent methyltransferase TehB -
NWE22_RS07410 (NWE22_07410) 1453620..1454663 + 1044 WP_277745332.1 alcohol dehydrogenase catalytic domain-containing protein -
NWE22_RS07415 (NWE22_07415) 1454822..1455271 - 450 WP_239604090.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NWE22_RS07420 (NWE22_07420) 1455309..1455491 - 183 WP_014637653.1 type II toxin-antitoxin system HicA family toxin Toxin
NWE22_RS07425 (NWE22_07425) 1455905..1456372 - 468 WP_277745333.1 SsrA-binding protein SmpB -
NWE22_RS07430 (NWE22_07430) 1456375..1458744 - 2370 WP_277745334.1 ribonuclease R -
NWE22_RS07435 (NWE22_07435) 1459008..1459241 - 234 WP_171989834.1 preprotein translocase subunit SecG -
NWE22_RS07440 (NWE22_07440) 1459288..1459437 - 150 WP_012775228.1 50S ribosomal protein L33 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-113)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6653.87 Da        Isoelectric Point: 10.8207

>T254118 WP_014637653.1 NZ_CP102747:c1455491-1455309 [Streptococcus parasuis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16620.60 Da        Isoelectric Point: 3.9788

>AT254118 WP_239604090.1 NZ_CP102747:c1455271-1454822 [Streptococcus parasuis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
HDEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SGM1

Antitoxin

Source ID Structure

References