Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 597095..597581 Replicon chromosome
Accession NZ_CP102746
Organism Streptococcus suis strain Transconjugant cAKJ47-2

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag NWE23_RS02970 Protein ID WP_011922754.1
Coordinates 597312..597581 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag NWE23_RS02965 Protein ID WP_002938604.1
Coordinates 597095..597322 (+) Length 76 a.a.

Genomic Context

NWE23_RS02945NWE23_RS02950NWE23_RS02955NWE23_RS02960NWE23_RS02965NWE23_RS02970NWE23_RS02975NWE23_RS02980NWE23_RS02985NWE23_RS02990NWE23_RS02995NWE23_RS02940
Location: 592881..593728 (848 bp)
Type: Others
Protein ID: WP_087892711.1
Location: 593787..594284 (498 bp)
Type: Others
Protein ID: WP_011922751.1
Location: 594281..595462 (1182 bp)
Type: Others
Protein ID: WP_011922154.1
Location: 595477..596823 (1347 bp)
Type: Others
Protein ID: WP_011922752.1
Location: 597095..597322 (228 bp)
Type: Antitoxin
Protein ID: WP_002938604.1
Location: 597312..597581 (270 bp)
Type: Toxin
Protein ID: WP_011922754.1
Location: 597987..599306 (1320 bp)
Type: Others
Protein ID: WP_012775027.1
Location: 599357..599734 (378 bp)
Type: Others
Protein ID: WP_002937263.1
Location: 599756..600643 (888 bp)
Type: Others
Protein ID: WP_011922160.1
Location: 600640..601614 (975 bp)
Type: Others
Protein ID: WP_002937257.1
Location: 601611..602528 (918 bp)
Type: Others
Protein ID: WP_002937252.1
Location: 592138..592587 (450 bp)
Type: Others
Protein ID: WP_009909619.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NWE23_RS02940 (NWE23_02945)592138..592587-450WP_009909619.1MarR family transcriptional regulator-
NWE23_RS02945 (NWE23_02950)592881..593728+848WP_087892711.1IS630 family transposase-
NWE23_RS02950 (NWE23_02955)593787..594284+498WP_011922751.1DUF5590 domain-containing protein-
NWE23_RS02955 (NWE23_02960)594281..595462+1182WP_011922154.1pyridoxal phosphate-dependent aminotransferase-
NWE23_RS02960 (NWE23_02965)595477..596823+1347WP_011922752.1asparagine--tRNA ligase-
NWE23_RS02965 (NWE23_02970)597095..597322+228WP_002938604.1DUF6290 family proteinAntitoxin
NWE23_RS02970 (NWE23_02975)597312..597581+270WP_011922754.1type II toxin-antitoxin system RelE/ParE family toxinToxin
NWE23_RS02975 (NWE23_02980)597987..599306+1320WP_012775027.1MATE family efflux transporter-
NWE23_RS02980 (NWE23_02985)599357..599734+378WP_002937263.1RidA family protein-
NWE23_RS02985 (NWE23_02990)599756..600643+888WP_011922160.1RNase adapter RapZ-
NWE23_RS02990 (NWE23_02995)600640..601614+975WP_002937257.1YvcK family protein-
NWE23_RS02995 (NWE23_03000)601611..602528+918WP_002937252.1DNA-binding protein WhiA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T254108 WP_011922754.1 NZ_CP102746:597312-597581 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT254108 WP_002938604.1 NZ_CP102746:597095-597322 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A126UKS2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A140EXF0

References