Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4685980..4686740 | Replicon | chromosome |
| Accession | NZ_CP102739 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky strain AH19MCS8 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A5H3Y7E3 |
| Locus tag | NWA03_RS22815 | Protein ID | WP_023225088.1 |
| Coordinates | 4685980..4686465 (-) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | A0A3Z2K6C6 |
| Locus tag | NWA03_RS22820 | Protein ID | WP_072106018.1 |
| Coordinates | 4686453..4686740 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NWA03_RS22785 (4681054) | 4681054..4681716 | + | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
| NWA03_RS22790 (4681935) | 4681935..4682909 | + | 975 | WP_023225087.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| NWA03_RS22795 (4682959) | 4682959..4683669 | - | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| NWA03_RS22800 (4684108) | 4684108..4684398 | + | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| NWA03_RS22805 (4684686) | 4684686..4684898 | + | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| NWA03_RS22810 (4685071) | 4685071..4685610 | + | 540 | WP_000047141.1 | copper-binding periplasmic metallochaperone CueP | - |
| NWA03_RS22815 (4685980) | 4685980..4686465 | - | 486 | WP_023225088.1 | GNAT family N-acetyltransferase | Toxin |
| NWA03_RS22820 (4686453) | 4686453..4686740 | - | 288 | WP_072106018.1 | DUF1778 domain-containing protein | Antitoxin |
| NWA03_RS22825 (4686863) | 4686863..4687891 | - | 1029 | WP_023196719.1 | HNH endonuclease signature motif containing protein | - |
| NWA03_RS22830 (4688918) | 4688918..4689688 | + | 771 | WP_000456879.1 | DUF3800 domain-containing protein | - |
| NWA03_RS22835 (4689884) | 4689884..4690312 | - | 429 | Protein_4443 | IS3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17756.43 Da Isoelectric Point: 9.0965
>T254101 WP_023225088.1 NZ_CP102739:c4686465-4685980 [Salmonella enterica subsp. enterica serovar Kentucky]
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10982.66 Da Isoelectric Point: 4.6811
>AT254101 WP_072106018.1 NZ_CP102739:c4686740-4686453 [Salmonella enterica subsp. enterica serovar Kentucky]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5H3Y7E3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3Z2K6C6 |