Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4685980..4686740 Replicon chromosome
Accession NZ_CP102739
Organism Salmonella enterica subsp. enterica serovar Kentucky strain AH19MCS8

Toxin (Protein)


Gene name tacT Uniprot ID A0A5H3Y7E3
Locus tag NWA03_RS22815 Protein ID WP_023225088.1
Coordinates 4685980..4686465 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A3Z2K6C6
Locus tag NWA03_RS22820 Protein ID WP_072106018.1
Coordinates 4686453..4686740 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA03_RS22785 (4681054) 4681054..4681716 + 663 WP_000747548.1 OmpA family lipoprotein -
NWA03_RS22790 (4681935) 4681935..4682909 + 975 WP_023225087.1 glyoxylate/hydroxypyruvate reductase GhrB -
NWA03_RS22795 (4682959) 4682959..4683669 - 711 WP_000190524.1 DUF3053 domain-containing protein -
NWA03_RS22800 (4684108) 4684108..4684398 + 291 WP_000455790.1 HTH-type transcriptional regulator -
NWA03_RS22805 (4684686) 4684686..4684898 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NWA03_RS22810 (4685071) 4685071..4685610 + 540 WP_000047141.1 copper-binding periplasmic metallochaperone CueP -
NWA03_RS22815 (4685980) 4685980..4686465 - 486 WP_023225088.1 GNAT family N-acetyltransferase Toxin
NWA03_RS22820 (4686453) 4686453..4686740 - 288 WP_072106018.1 DUF1778 domain-containing protein Antitoxin
NWA03_RS22825 (4686863) 4686863..4687891 - 1029 WP_023196719.1 HNH endonuclease signature motif containing protein -
NWA03_RS22830 (4688918) 4688918..4689688 + 771 WP_000456879.1 DUF3800 domain-containing protein -
NWA03_RS22835 (4689884) 4689884..4690312 - 429 Protein_4443 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17756.43 Da        Isoelectric Point: 9.0965

>T254101 WP_023225088.1 NZ_CP102739:c4686465-4685980 [Salmonella enterica subsp. enterica serovar Kentucky]
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10982.66 Da        Isoelectric Point: 4.6811

>AT254101 WP_072106018.1 NZ_CP102739:c4686740-4686453 [Salmonella enterica subsp. enterica serovar Kentucky]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H3Y7E3

Antitoxin

Source ID Structure
AlphaFold DB A0A3Z2K6C6

References