Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4581917..4582708 Replicon chromosome
Accession NZ_CP102739
Organism Salmonella enterica subsp. enterica serovar Kentucky strain AH19MCS8

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag NWA03_RS22355 Protein ID WP_000369560.1
Coordinates 4581917..4582435 (-) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag NWA03_RS22360 Protein ID WP_001275017.1
Coordinates 4582439..4582708 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA03_RS22330 (4576982) 4576982..4577749 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
NWA03_RS22335 (4577746) 4577746..4579023 - 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
NWA03_RS22340 (4579020) 4579020..4579946 - 927 WP_000003005.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NWA03_RS22345 (4580006) 4580006..4581115 - 1110 WP_023224165.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NWA03_RS22350 (4581537) 4581537..4581920 + 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
NWA03_RS22355 (4581917) 4581917..4582435 - 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
NWA03_RS22360 (4582439) 4582439..4582708 - 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
NWA03_RS22365 (4582886) 4582886..4583989 - 1104 WP_001533929.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NWA03_RS22370 (4584311) 4584311..4585165 - 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
NWA03_RS22375 (4585411) 4585411..4586466 - 1056 WP_001081707.1 permease-like cell division protein FtsX -
NWA03_RS22380 (4586459) 4586459..4587127 - 669 WP_000617729.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T254100 WP_000369560.1 NZ_CP102739:c4582435-4581917 [Salmonella enterica subsp. enterica serovar Kentucky]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT254100 WP_001275017.1 NZ_CP102739:c4582708-4582439 [Salmonella enterica subsp. enterica serovar Kentucky]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References