Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 23208..23700 Replicon plasmid pZYMOP02
Accession NC_015716
Organism Zymomonas mobilis subsp. pomaceae ATCC 29192

Toxin (Protein)


Gene name pasB Uniprot ID F8EWJ3
Locus tag ZYMOP_RS09100 Protein ID WP_013945643.1
Coordinates 23416..23700 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID F8EWJ2
Locus tag ZYMOP_RS09095 Protein ID WP_013945642.1
Coordinates 23208..23432 (+) Length 75 a.a.

Genomic Context

ZYMOP_RS09375ZYMOP_RS09270ZYMOP_RS09075ZYMOP_RS09090ZYMOP_RS09095ZYMOP_RS09100ZYMOP_RS09105ZYMOP_RS09110ZYMOP_RS09115ZYMOP_RS09475ZYMOP_RS09380ZYMOP_RS09125ZYMOP_RS09130ZYMOP_RS09135ZYMOP_RS09140
Location: 18657..18899 (243 bp)
Type: Others
Protein ID: Protein_12
Location: 18871..19395 (525 bp)
Type: Others
Protein ID: WP_049778896.1
Location: 19380..19835 (456 bp)
Type: Others
Protein ID: WP_049778897.1
Location: 21062..22057 (996 bp)
Type: Others
Protein ID: WP_013945641.1
Location: 23208..23432 (225 bp)
Type: Antitoxin
Protein ID: WP_013945642.1
Location: 23416..23700 (285 bp)
Type: Toxin
Protein ID: WP_013945643.1
Location: 23835..24467 (633 bp)
Type: Others
Protein ID: WP_013945644.1
Location: 24464..24739 (276 bp)
Type: Others
Protein ID: WP_013945645.1
Location: 25422..25667 (246 bp)
Type: Others
Protein ID: WP_049778898.1
Location: 28465..28629 (165 bp)
Type: Others
Protein ID: WP_013945652.1
Location: 22375..22638 (264 bp)
Type: Others
Protein ID: WP_080558593.1
Location: 27019..27339 (321 bp)
Type: Others
Protein ID: WP_013945648.1
Location: 27348..27728 (381 bp)
Type: Others
Protein ID: WP_013945649.1
Location: 27725..27955 (231 bp)
Type: Others
Protein ID: WP_013945650.1
Location: 28098..28280 (183 bp)
Type: Others
Protein ID: WP_013945651.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ZYMOP_RS0937518657..18899+243Protein_12transposase-
ZYMOP_RS0927018871..19395+525WP_049778896.1hypothetical protein-
ZYMOP_RS0907519380..19835+456WP_049778897.1hypothetical protein-
ZYMOP_RS0909021062..22057+996WP_013945641.1NADP-dependent oxidoreductase-
ZYMOP_RS0938022375..22638-264WP_080558593.1Na+/H+ antiporter NhaA-
ZYMOP_RS0909523208..23432+225WP_013945642.1TraY domain-containing proteinAntitoxin
ZYMOP_RS0910023416..23700+285WP_013945643.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ZYMOP_RS0910523835..24467+633WP_013945644.1ParA family protein-
ZYMOP_RS0911024464..24739+276WP_013945645.1hypothetical protein-
ZYMOP_RS0911525422..25667+246WP_049778898.1helix-turn-helix domain-containing protein-
ZYMOP_RS0912527019..27339-321WP_013945648.1DUF1870 family protein-
ZYMOP_RS0913027348..27728-381WP_013945649.1type II toxin-antitoxin system death-on-curing family toxin-
ZYMOP_RS0913527725..27955-231WP_013945650.1hypothetical protein-
ZYMOP_RS0914028098..28280-183WP_013945651.1hypothetical protein-
ZYMOP_RS0947528465..28629+165WP_013945652.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..3416134161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Relaxosome protein TraY

(4-49)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10877.88 Da        Isoelectric Point: 10.9851

>T25410 WP_013945643.1 NC_015716:23416-23700 [Zymomonas mobilis subsp. pomaceae ATCC 29192]
MAWKIEFDPAAQKELRKLGVQPAKRILKFLSERLALSDNPRSLGAALKGTTLGSLWKYRIGDYRIIVDIEDNVMRILVIR
IGNRKEIYKKSVRH

Download         Length: 285 bp

>T25410 NC_015716:23416-23700 [Zymomonas mobilis subsp. pomaceae ATCC 29192]
ATGGCTTGGAAAATTGAATTCGATCCAGCCGCTCAAAAAGAGTTAAGAAAACTAGGGGTACAGCCCGCAAAGCGTATCTT
GAAATTTTTATCTGAACGTTTGGCATTATCGGATAATCCAAGGTCATTAGGCGCTGCTTTAAAAGGGACAACGCTGGGTA
GTTTATGGAAATATCGAATTGGCGATTACCGCATTATTGTCGATATTGAAGATAATGTAATGCGGATTCTGGTTATCAGA
ATTGGTAATAGAAAAGAAATTTATAAAAAATCCGTTAGGCATTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8480.70 Da        Isoelectric Point: 4.5173

>AT25410 WP_013945642.1 NC_015716:23208-23432 [Zymomonas mobilis subsp. pomaceae ATCC 29192]
MLAIRLPEEIEDRLSELAKATGRTKTFYAREAILQHLEELEDIYLAEARAIKIRSGETKTISLDNVMVEYGLEN

Download         Length: 225 bp

>AT25410 NC_015716:23208-23432 [Zymomonas mobilis subsp. pomaceae ATCC 29192]
ATGTTGGCAATTCGTTTACCAGAAGAAATTGAAGATCGTCTAAGCGAACTGGCGAAGGCCACGGGGCGGACAAAAACTTT
TTATGCAAGAGAAGCTATTCTTCAGCATCTAGAAGAACTGGAAGATATCTATCTTGCCGAGGCACGTGCTATCAAAATTC
GTTCCGGAGAAACCAAAACCATTTCTTTAGATAACGTCATGGTTGAATATGGCTTGGAAAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBF8EWJ3

Antitoxin

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Source
ID
Structure
AlphaFold DBF8EWJ2

References