Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4047573..4048233 Replicon chromosome
Accession NZ_CP102739
Organism Salmonella enterica subsp. enterica serovar Kentucky strain AH19MCS8

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NWA03_RS19670 Protein ID WP_000244756.1
Coordinates 4047573..4047986 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NWA03_RS19675 Protein ID WP_000351186.1
Coordinates 4047967..4048233 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA03_RS19650 (4043514) 4043514..4045247 - 1734 WP_023223830.1 single-stranded-DNA-specific exonuclease RecJ -
NWA03_RS19655 (4045253) 4045253..4045966 - 714 WP_023223829.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NWA03_RS19660 (4045990) 4045990..4046886 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NWA03_RS19665 (4046999) 4046999..4047520 + 522 WP_001055885.1 flavodoxin FldB -
NWA03_RS19670 (4047573) 4047573..4047986 - 414 WP_000244756.1 protein YgfX Toxin
NWA03_RS19675 (4047967) 4047967..4048233 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NWA03_RS19680 (4048483) 4048483..4049463 + 981 WP_000874178.1 tRNA-modifying protein YgfZ -
NWA03_RS19685 (4049579) 4049579..4050238 - 660 WP_000250289.1 hemolysin III family protein -
NWA03_RS19690 (4050402) 4050402..4050713 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NWA03_RS19695 (4050871) 4050871..4052304 + 1434 WP_001230143.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T254099 WP_000244756.1 NZ_CP102739:c4047986-4047573 [Salmonella enterica subsp. enterica serovar Kentucky]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT254099 WP_000351186.1 NZ_CP102739:c4048233-4047967 [Salmonella enterica subsp. enterica serovar Kentucky]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References