Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3879256..3880070 Replicon chromosome
Accession NZ_CP102739
Organism Salmonella enterica subsp. enterica serovar Kentucky strain AH19MCS8

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag NWA03_RS18900 Protein ID WP_000971653.1
Coordinates 3879543..3880070 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NWA03_RS18895 Protein ID WP_000855694.1
Coordinates 3879256..3879546 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA03_RS18865 (3875181) 3875181..3875831 - 651 WP_072203970.1 type III secretion system transcriptional activator InvF -
NWA03_RS18870 (3876289) 3876289..3876732 + 444 WP_023225039.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NWA03_RS18875 (3877164) 3877164..3877613 + 450 WP_023225038.1 hypothetical protein -
NWA03_RS18880 (3877598) 3877598..3877945 + 348 WP_001555786.1 DUF1493 family protein -
NWA03_RS18885 (3878218) 3878218..3878544 - 327 WP_000393295.1 hypothetical protein -
NWA03_RS18890 (3878785) 3878785..3878985 + 201 Protein_3672 transposase -
NWA03_RS18895 (3879256) 3879256..3879546 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NWA03_RS18900 (3879543) 3879543..3880070 + 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
NWA03_RS18905 (3880143) 3880143..3880345 - 203 Protein_3675 IS5/IS1182 family transposase -
NWA03_RS18910 (3880695) 3880695..3881351 + 657 WP_023225036.1 protein-serine/threonine phosphatase -
NWA03_RS18915 (3881523) 3881523..3882017 - 495 WP_000424946.1 hypothetical protein -
NWA03_RS18920 (3882044) 3882044..3882712 - 669 WP_000445914.1 hypothetical protein -
NWA03_RS18925 (3882869) 3882869..3883087 - 219 Protein_3679 hypothetical protein -
NWA03_RS18930 (3883298) 3883298..3883696 - 399 Protein_3680 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3878785..3880319 1534


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T254098 WP_000971653.1 NZ_CP102739:3879543-3880070 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT254098 WP_000855694.1 NZ_CP102739:3879256-3879546 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References