254093

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2475872..2476394 Replicon chromosome
Accession NZ_CP102739
Organism Salmonella enterica subsp. enterica serovar Kentucky strain AH19MCS8

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag NWA03_RS12020 Protein ID WP_000221345.1
Coordinates 2475872..2476156 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NWA03_RS12025 Protein ID WP_000885424.1
Coordinates 2476146..2476394 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA03_RS12000 (2471947) 2471947..2473455 - 1509 WP_023223898.1 FAD-dependent oxidoreductase -
NWA03_RS12005 (2473500) 2473500..2473988 + 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
NWA03_RS12010 (2474181) 2474181..2475260 + 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NWA03_RS12015 (2475312) 2475312..2475701 - 390 WP_000194089.1 RidA family protein -
NWA03_RS12020 (2475872) 2475872..2476156 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWA03_RS12025 (2476146) 2476146..2476394 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NWA03_RS12030 (2476546) 2476546..2476665 + 120 Protein_2334 type II and III secretion system -
NWA03_RS12035 (2476751) 2476751..2477082 + 332 Protein_2335 DUF1493 family protein -
NWA03_RS12040 (2477355) 2477355..2478263 + 909 WP_077906523.1 hypothetical protein -
NWA03_RS12045 (2478265) 2478265..2479004 - 740 Protein_2337 hypothetical protein -
NWA03_RS12050 (2479370) 2479370..2479558 - 189 WP_001276021.1 DUF29 family protein -
NWA03_RS12055 (2479960) 2479960..2480244 + 285 Protein_2339 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2474181..2485874 11693


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T254093 WP_000221345.1 NZ_CP102739:c2476156-2475872 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT254093 WP_000885424.1 NZ_CP102739:c2476394-2476146 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References