Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1482483..1483103 Replicon chromosome
Accession NZ_CP102739
Organism Salmonella enterica subsp. enterica serovar Kentucky strain AH19MCS8

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NWA03_RS07110 Protein ID WP_001280991.1
Coordinates 1482483..1482701 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NWA03_RS07115 Protein ID WP_000344807.1
Coordinates 1482729..1483103 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA03_RS07070 (1477706) 1477706..1478275 + 570 WP_000779802.1 YbaY family lipoprotein -
NWA03_RS07075 (1478308) 1478308..1478697 - 390 WP_023224410.1 MGMT family protein -
NWA03_RS07085 (1478928) 1478928..1480478 - 1551 WP_000213145.1 EAL domain-containing protein -
NWA03_RS07090 (1480703) 1480703..1480963 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NWA03_RS07095 (1480969) 1480969..1481109 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NWA03_RS07100 (1481165) 1481165..1481635 - 471 WP_000136183.1 YlaC family protein -
NWA03_RS07105 (1481753) 1481753..1482304 - 552 WP_001278793.1 maltose O-acetyltransferase -
NWA03_RS07110 (1482483) 1482483..1482701 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NWA03_RS07115 (1482729) 1482729..1483103 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NWA03_RS07120 (1483599) 1483599..1486748 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NWA03_RS07125 (1486771) 1486771..1487964 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T254092 WP_001280991.1 NZ_CP102739:c1482701-1482483 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT254092 WP_000344807.1 NZ_CP102739:c1483103-1482729 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References