Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 894172..895795 | Replicon | chromosome |
| Accession | NZ_CP102739 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky strain AH19MCS8 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | H9TH67 |
| Locus tag | NWA03_RS04290 | Protein ID | WP_000088046.1 |
| Coordinates | 894172..895497 (-) | Length | 442 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
| Locus tag | NWA03_RS04295 | Protein ID | WP_024136327.1 |
| Coordinates | 895502..895795 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NWA03_RS04255 (889441) | 889441..889614 | - | 174 | WP_224435200.1 | hypothetical protein | - |
| NWA03_RS04260 (889710) | 889710..891245 | - | 1536 | WP_001000406.1 | IS66 family transposase | - |
| NWA03_RS04265 (891295) | 891295..891642 | - | 348 | WP_000609174.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| NWA03_RS04270 (892102) | 892102..892311 | - | 210 | WP_223533973.1 | hypothetical protein | - |
| NWA03_RS04275 (892565) | 892565..893380 | - | 816 | WP_001572439.1 | HNH endonuclease signature motif containing protein | - |
| NWA03_RS04280 (893393) | 893393..893803 | - | 411 | WP_000985911.1 | hypothetical protein | - |
| NWA03_RS04285 (893905) | 893905..894111 | - | 207 | WP_000134171.1 | hypothetical protein | - |
| NWA03_RS04290 (894172) | 894172..895497 | - | 1326 | WP_000088046.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| NWA03_RS04295 (895502) | 895502..895795 | - | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| NWA03_RS04300 (896399) | 896399..896791 | - | 393 | WP_000341066.1 | hypothetical protein | - |
| NWA03_RS04305 (897164) | 897164..897499 | + | 336 | WP_065311125.1 | hypothetical protein | - |
| NWA03_RS04310 (897538) | 897538..898335 | - | 798 | WP_000544828.1 | IS21-like element IS21 family helper ATPase IstB | - |
| NWA03_RS04315 (898335) | 898335..899507 | - | 1173 | WP_000952349.1 | IS21-like element IS21 family transposase | - |
| NWA03_RS04320 (899573) | 899573..900028 | + | 456 | WP_224435199.1 | hypothetical protein | - |
| NWA03_RS04325 (900094) | 900094..900375 | + | 282 | WP_000710431.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | aph(3')-Ia / dfrA14 / ARR-3 / ant(3'')-Ia / lnu(F) / aac(3)-IId / floR / blaCTX-M-55 / blaTEM-1B / fosA3 / rmtB | - | 884064..951402 | 67338 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50249.20 Da Isoelectric Point: 6.1927
>T254089 WP_000088046.1 NZ_CP102739:c895497-894172 [Salmonella enterica subsp. enterica serovar Kentucky]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10946.35 Da Isoelectric Point: 10.0925
>AT254089 WP_024136327.1 NZ_CP102739:c895795-895502 [Salmonella enterica subsp. enterica serovar Kentucky]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3T0VBU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Z6V2D1 |