Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4751821..4752581 | Replicon | chromosome |
| Accession | NZ_CP102719 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS1 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A5H3Y7E3 |
| Locus tag | NWA05_RS23255 | Protein ID | WP_023225088.1 |
| Coordinates | 4751821..4752306 (-) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | A0A3Z2K6C6 |
| Locus tag | NWA05_RS23260 | Protein ID | WP_072106018.1 |
| Coordinates | 4752294..4752581 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NWA05_RS23225 (4746895) | 4746895..4747557 | + | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
| NWA05_RS23230 (4747776) | 4747776..4748750 | + | 975 | WP_023225087.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| NWA05_RS23235 (4748800) | 4748800..4749510 | - | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| NWA05_RS23240 (4749949) | 4749949..4750239 | + | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| NWA05_RS23245 (4750527) | 4750527..4750739 | + | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| NWA05_RS23250 (4750912) | 4750912..4751451 | + | 540 | WP_000047141.1 | copper-binding periplasmic metallochaperone CueP | - |
| NWA05_RS23255 (4751821) | 4751821..4752306 | - | 486 | WP_023225088.1 | GNAT family N-acetyltransferase | Toxin |
| NWA05_RS23260 (4752294) | 4752294..4752581 | - | 288 | WP_072106018.1 | DUF1778 domain-containing protein | Antitoxin |
| NWA05_RS23265 (4752704) | 4752704..4753732 | - | 1029 | WP_023196719.1 | HNH endonuclease signature motif containing protein | - |
| NWA05_RS23270 (4754759) | 4754759..4755529 | + | 771 | WP_000456879.1 | DUF3800 domain-containing protein | - |
| NWA05_RS23275 (4755725) | 4755725..4756153 | - | 429 | Protein_4531 | IS3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17756.43 Da Isoelectric Point: 9.0965
>T254084 WP_023225088.1 NZ_CP102719:c4752306-4751821 [Salmonella enterica subsp. enterica serovar Kentucky]
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10982.66 Da Isoelectric Point: 4.6811
>AT254084 WP_072106018.1 NZ_CP102719:c4752581-4752294 [Salmonella enterica subsp. enterica serovar Kentucky]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5H3Y7E3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3Z2K6C6 |