254081

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3945645..3946459 Replicon chromosome
Accession NZ_CP102719
Organism Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS1

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag NWA05_RS19350 Protein ID WP_000971653.1
Coordinates 3945932..3946459 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NWA05_RS19345 Protein ID WP_000855694.1
Coordinates 3945645..3945935 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA05_RS19315 (3941570) 3941570..3942220 - 651 WP_072203970.1 type III secretion system transcriptional activator InvF -
NWA05_RS19320 (3942678) 3942678..3943121 + 444 WP_023225039.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NWA05_RS19325 (3943553) 3943553..3944002 + 450 WP_023225038.1 hypothetical protein -
NWA05_RS19330 (3943987) 3943987..3944334 + 348 WP_001555786.1 DUF1493 family protein -
NWA05_RS19335 (3944607) 3944607..3944933 - 327 WP_000393295.1 hypothetical protein -
NWA05_RS19340 (3945174) 3945174..3945374 + 201 Protein_3762 transposase -
NWA05_RS19345 (3945645) 3945645..3945935 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NWA05_RS19350 (3945932) 3945932..3946459 + 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
NWA05_RS19355 (3946532) 3946532..3946734 - 203 Protein_3765 IS5/IS1182 family transposase -
NWA05_RS19360 (3947084) 3947084..3947740 + 657 WP_023225036.1 protein-serine/threonine phosphatase -
NWA05_RS19365 (3947912) 3947912..3948406 - 495 WP_000424946.1 hypothetical protein -
NWA05_RS19370 (3948433) 3948433..3949101 - 669 WP_000445914.1 hypothetical protein -
NWA05_RS19375 (3949258) 3949258..3949476 - 219 Protein_3769 hypothetical protein -
NWA05_RS19380 (3949687) 3949687..3950085 - 399 Protein_3770 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3945174..3946708 1534


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T254081 WP_000971653.1 NZ_CP102719:3945932-3946459 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT254081 WP_000855694.1 NZ_CP102719:3945645-3945935 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References