254076

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2500002..2500524 Replicon chromosome
Accession NZ_CP102719
Organism Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS1

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag NWA05_RS12140 Protein ID WP_000221345.1
Coordinates 2500002..2500286 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NWA05_RS12145 Protein ID WP_000885424.1
Coordinates 2500276..2500524 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA05_RS12120 (2496077) 2496077..2497585 - 1509 WP_023223898.1 FAD-dependent oxidoreductase -
NWA05_RS12125 (2497630) 2497630..2498118 + 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
NWA05_RS12130 (2498311) 2498311..2499390 + 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NWA05_RS12135 (2499442) 2499442..2499831 - 390 WP_000194089.1 RidA family protein -
NWA05_RS12140 (2500002) 2500002..2500286 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWA05_RS12145 (2500276) 2500276..2500524 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NWA05_RS12150 (2500676) 2500676..2500795 + 120 Protein_2359 type II and III secretion system -
NWA05_RS12155 (2500881) 2500881..2501212 + 332 Protein_2360 DUF1493 family protein -
NWA05_RS12160 (2501485) 2501485..2502393 + 909 WP_077906523.1 hypothetical protein -
NWA05_RS12165 (2502395) 2502395..2503134 - 740 Protein_2362 hypothetical protein -
NWA05_RS12170 (2503500) 2503500..2503688 - 189 WP_001276021.1 DUF29 family protein -
NWA05_RS12175 (2504090) 2504090..2504818 + 729 WP_240856007.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2498311..2510003 11692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T254076 WP_000221345.1 NZ_CP102719:c2500286-2500002 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT254076 WP_000885424.1 NZ_CP102719:c2500524-2500276 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References