Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1506792..1507412 Replicon chromosome
Accession NZ_CP102719
Organism Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NWA05_RS07235 Protein ID WP_001280991.1
Coordinates 1506792..1507010 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NWA05_RS07240 Protein ID WP_000344807.1
Coordinates 1507038..1507412 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA05_RS07195 (1502015) 1502015..1502584 + 570 WP_000779802.1 YbaY family lipoprotein -
NWA05_RS07200 (1502617) 1502617..1503006 - 390 WP_023224410.1 MGMT family protein -
NWA05_RS07210 (1503237) 1503237..1504787 - 1551 WP_000213145.1 EAL domain-containing protein -
NWA05_RS07215 (1505012) 1505012..1505272 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NWA05_RS07220 (1505278) 1505278..1505418 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NWA05_RS07225 (1505474) 1505474..1505944 - 471 WP_000136183.1 YlaC family protein -
NWA05_RS07230 (1506062) 1506062..1506613 - 552 WP_001278793.1 maltose O-acetyltransferase -
NWA05_RS07235 (1506792) 1506792..1507010 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NWA05_RS07240 (1507038) 1507038..1507412 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NWA05_RS07245 (1507908) 1507908..1511057 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NWA05_RS07250 (1511080) 1511080..1512273 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T254075 WP_001280991.1 NZ_CP102719:c1507010-1506792 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT254075 WP_000344807.1 NZ_CP102719:c1507412-1507038 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References