Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 892036..893659 | Replicon | chromosome |
| Accession | NZ_CP102719 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS1 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | H9TH67 |
| Locus tag | NWA05_RS04280 | Protein ID | WP_000088046.1 |
| Coordinates | 892036..893361 (-) | Length | 442 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
| Locus tag | NWA05_RS04285 | Protein ID | WP_024136327.1 |
| Coordinates | 893366..893659 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NWA05_RS04245 (887305) | 887305..887478 | - | 174 | WP_224435200.1 | hypothetical protein | - |
| NWA05_RS04250 (887574) | 887574..889109 | - | 1536 | WP_001000406.1 | IS66 family transposase | - |
| NWA05_RS04255 (889159) | 889159..889506 | - | 348 | WP_000609174.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| NWA05_RS04260 (889966) | 889966..890175 | - | 210 | WP_223533973.1 | hypothetical protein | - |
| NWA05_RS04265 (890429) | 890429..891244 | - | 816 | WP_001572439.1 | HNH endonuclease signature motif containing protein | - |
| NWA05_RS04270 (891257) | 891257..891667 | - | 411 | WP_000985911.1 | hypothetical protein | - |
| NWA05_RS04275 (891769) | 891769..891975 | - | 207 | WP_000134171.1 | hypothetical protein | - |
| NWA05_RS04280 (892036) | 892036..893361 | - | 1326 | WP_000088046.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| NWA05_RS04285 (893366) | 893366..893659 | - | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| NWA05_RS04290 (894263) | 894263..894655 | - | 393 | WP_000341066.1 | hypothetical protein | - |
| NWA05_RS04295 (895028) | 895028..895363 | + | 336 | WP_065311125.1 | hypothetical protein | - |
| NWA05_RS04300 (895402) | 895402..896199 | - | 798 | WP_000544828.1 | IS21-like element IS21 family helper ATPase IstB | - |
| NWA05_RS04305 (896199) | 896199..897371 | - | 1173 | WP_000952349.1 | IS21-like element IS21 family transposase | - |
| NWA05_RS04310 (897437) | 897437..897892 | + | 456 | WP_224435199.1 | hypothetical protein | - |
| NWA05_RS04315 (897958) | 897958..898239 | + | 282 | WP_000710431.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | aph(3')-Ia / mph(A) / ant(3'')-Ia / lnu(F) / aac(3)-IId / blaTEM-1B / rmtB / fosA3 / blaCTX-M-55 / qnrS1 / aac(3)-IVa / floR | - | 881928..978158 | 96230 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50249.20 Da Isoelectric Point: 6.1927
>T254072 WP_000088046.1 NZ_CP102719:c893361-892036 [Salmonella enterica subsp. enterica serovar Kentucky]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10946.35 Da Isoelectric Point: 10.0925
>AT254072 WP_024136327.1 NZ_CP102719:c893659-893366 [Salmonella enterica subsp. enterica serovar Kentucky]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3T0VBU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Z6V2D1 |