Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 542391..543172 Replicon chromosome
Accession NZ_CP102719
Organism Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS1

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag NWA05_RS02560 Protein ID WP_000625911.1
Coordinates 542681..543172 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag NWA05_RS02555 Protein ID WP_001271379.1
Coordinates 542391..542684 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA05_RS02520 (538691) 538691..539596 + 906 WP_001268192.1 YjiK family protein -
NWA05_RS02525 (539891) 539891..540085 - 195 WP_223163373.1 hypothetical protein -
NWA05_RS02530 (540133) 540133..540232 - 100 Protein_477 hypothetical protein -
NWA05_RS02535 (540252) 540252..540434 + 183 WP_072106065.1 ATP-binding cassette domain-containing protein -
NWA05_RS02540 (540427) 540427..540714 - 288 WP_072103482.1 transcriptional regulator RtsB -
NWA05_RS02545 (540711) 540711..541586 - 876 WP_023205266.1 AraC family transcriptional regulator -
NWA05_RS02550 (541852) 541852..542073 - 222 WP_052939504.1 hypothetical protein -
NWA05_RS02555 (542391) 542391..542684 + 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
NWA05_RS02560 (542681) 542681..543172 + 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
NWA05_RS02565 (543387) 543387..543635 + 249 Protein_484 IS481 family transposase -
NWA05_RS02570 (543910) 543910..544137 - 228 WP_001112992.1 hypothetical protein -
NWA05_RS02575 (544730) 544730..545014 + 285 WP_192917775.1 PapB/FocB family fimbrial expression transcriptional regulator -
NWA05_RS02580 (545049) 545049..545588 + 540 WP_000721295.1 type 1 fimbrial protein -
NWA05_RS02585 (545598) 545598..548036 + 2439 WP_023224120.1 F4 (K88) fimbrial usher FaeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeC / faeD / faeE / faeF / faeH / faeI 540427..556194 15767


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T254070 WP_000625911.1 NZ_CP102719:542681-543172 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT254070 WP_001271379.1 NZ_CP102719:542391-542684 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References