Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 21999..22642 Replicon plasmid pGN4554-3
Accession NZ_CP102697
Organism Escherichia coli strain GN4554

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag NV952_RS23935 Protein ID WP_001034044.1
Coordinates 22226..22642 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag NV952_RS23930 Protein ID WP_001261286.1
Coordinates 21999..22229 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV952_RS23910 (18630) 18630..19385 - 756 WP_000852146.1 replication initiation protein RepE -
NV952_RS23915 (20107) 20107..20913 - 807 WP_000016970.1 site-specific integrase -
NV952_RS23920 (20914) 20914..21219 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB -
NV952_RS23925 (21221) 21221..21439 - 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA -
NV952_RS23930 (21999) 21999..22229 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NV952_RS23935 (22226) 22226..22642 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
NV952_RS23940 (22717) 22717..24282 + 1566 WP_001128474.1 AAA family ATPase -
NV952_RS23945 (24267) 24267..25289 + 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sitABCD iutA / iucD / iucC / iucB / iucA 1..54149 54149


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T254057 WP_001034044.1 NZ_CP102697:22226-22642 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT254057 WP_001261286.1 NZ_CP102697:21999-22229 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References