Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 743310..743743 Replicon chromosome
Accession NC_015681
Organism Thermodesulfatator indicus DSM 15286

Toxin (Protein)


Gene name hicA Uniprot ID F8AC28
Locus tag THEIN_RS03545 Protein ID WP_013907328.1
Coordinates 743516..743743 (+) Length 76 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID F8AC27
Locus tag THEIN_RS03540 Protein ID WP_013907327.1
Coordinates 743310..743519 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THEIN_RS03520 739415..740512 + 1098 WP_013907323.1 LptF/LptG family permease -
THEIN_RS03525 740513..741586 + 1074 WP_013907324.1 LptF/LptG family permease -
THEIN_RS03530 741589..742395 + 807 WP_013907325.1 menaquinone biosynthesis protein -
THEIN_RS03535 742395..743264 + 870 WP_013907326.1 DUF3473 domain-containing protein -
THEIN_RS03540 743310..743519 + 210 WP_013907327.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
THEIN_RS03545 743516..743743 + 228 WP_013907328.1 type II toxin-antitoxin system HicA family toxin Toxin
THEIN_RS03550 743965..744171 + 207 WP_013907329.1 hypothetical protein -
THEIN_RS03555 744153..744413 + 261 WP_013907330.1 type II toxin-antitoxin system RelE/ParE family toxin -
THEIN_RS03560 744802..745809 + 1008 WP_013907331.1 GNAT family N-acetyltransferase -
THEIN_RS03565 745806..746990 + 1185 WP_013907332.1 TIGR03087 family PEP-CTERM/XrtA system glycosyltransferase -
THEIN_RS03570 746974..748101 + 1128 WP_013907333.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(9-66)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-53)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8656.36 Da        Isoelectric Point: 10.9651

>T25405 WP_013907328.1 NC_015681:743516-743743 [Thermodesulfatator indicus DSM 15286]
MSKVPSLNYDKVIKALQRDGWVVVRQKGSHIRLHKYTKDKKLKLIVPAHKPIKRSTLSHILKQAGLSVEEFLELL

Download         Length: 228 bp

>T25405 NC_015681:743516-743743 [Thermodesulfatator indicus DSM 15286]
ATGAGTAAAGTCCCTAGCCTAAACTATGATAAAGTAATAAAAGCTCTCCAGAGAGATGGATGGGTTGTGGTGCGGCAGAA
AGGGAGCCATATAAGGCTTCATAAATACACGAAAGATAAGAAATTGAAATTAATAGTTCCTGCACATAAACCGATTAAAA
GATCAACTTTATCTCATATTTTAAAACAAGCAGGATTAAGTGTGGAAGAATTTTTGGAACTTTTATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7637.77 Da        Isoelectric Point: 3.8062

>AT25405 WP_013907327.1 NC_015681:743310-743519 [Thermodesulfatator indicus DSM 15286]
MKLKIVLEPSEEGGYTVYVPGLPGCISEGDTVEEALQNIKEAIELYLEPVEDDLVSFAEKQVKIIELTI

Download         Length: 210 bp

>AT25405 NC_015681:743310-743519 [Thermodesulfatator indicus DSM 15286]
ATGAAACTTAAAATCGTTTTAGAACCTAGCGAAGAAGGTGGATATACCGTATATGTTCCCGGATTGCCAGGATGTATTAG
TGAAGGTGATACTGTAGAAGAAGCCCTTCAGAATATTAAAGAAGCTATAGAGTTATACCTTGAGCCCGTTGAAGATGATT
TAGTCTCTTTTGCAGAAAAGCAAGTCAAAATAATAGAGTTAACTATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8AC28

Antitoxin

Source ID Structure
AlphaFold DB F8AC27

References