Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1774..2321 Replicon plasmid pGN4554-2
Accession NZ_CP102696
Organism Escherichia coli strain GN4554

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag NV952_RS23370 Protein ID WP_001384452.1
Coordinates 2043..2321 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag NV952_RS23365 Protein ID WP_171935525.1
Coordinates 1774..2043 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV952_RS23360 (1) 1..858 + 858 WP_012817826.1 incFII family plasmid replication initiator RepA -
NV952_RS23365 (1774) 1774..2043 + 270 WP_171935525.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
NV952_RS23370 (2043) 2043..2321 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
NV952_RS23375 (2618) 2618..3817 - 1200 WP_000948429.1 IS91 family transposase -
NV952_RS23380 (3827) 3827..4015 - 189 WP_000957857.1 hypothetical protein -
NV952_RS23385 (4454) 4454..5674 + 1221 WP_072664738.1 autotransporter strand-loop-strand O-heptosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..67067 67067
- flank IS/Tn - - 2618..3817 1199


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T254049 WP_001384452.1 NZ_CP102696:2043-2321 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10254.56 Da        Isoelectric Point: 7.2057

>AT254049 WP_171935525.1 NZ_CP102696:1774-2043 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSATAWRD
EMSRKAAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure

References