Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4210493..4210990 Replicon chromosome
Accession NZ_CP102694
Organism Escherichia coli strain GN4554

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NV952_RS20625 Protein ID WP_001173343.1
Coordinates 4210493..4210666 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag NV952_RS20630 Protein ID WP_001425728.1
Coordinates 4210694..4210990 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV952_RS20615 (4207163) 4207163..4208620 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
NV952_RS20620 (4208857) 4208857..4210374 + 1518 WP_001295074.1 lysine--tRNA ligase -
NV952_RS20625 (4210493) 4210493..4210666 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NV952_RS20630 (4210694) 4210694..4210990 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NV952_RS20635 (4211217) 4211217..4211489 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
NV952_RS20640 (4211501) 4211501..4211731 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
NV952_RS20645 (4211912) 4211912..4213543 + 1632 WP_001216487.1 sensor histidine kinase -
NV952_RS20650 (4213540) 4213540..4214259 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T254047 WP_001173343.1 NZ_CP102694:c4210666-4210493 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT254047 WP_001425728.1 NZ_CP102694:c4210990-4210694 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References