Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3418130..3418748 Replicon chromosome
Accession NZ_CP102694
Organism Escherichia coli strain GN4554

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NV952_RS16720 Protein ID WP_001291435.1
Coordinates 3418530..3418748 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NV952_RS16715 Protein ID WP_000344800.1
Coordinates 3418130..3418504 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV952_RS16705 (3413219) 3413219..3414412 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NV952_RS16710 (3414435) 3414435..3417584 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NV952_RS16715 (3418130) 3418130..3418504 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NV952_RS16720 (3418530) 3418530..3418748 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NV952_RS16725 (3418920) 3418920..3419471 + 552 WP_000102568.1 maltose O-acetyltransferase -
NV952_RS16730 (3419587) 3419587..3420057 + 471 WP_000136192.1 YlaC family protein -
NV952_RS16735 (3420221) 3420221..3421771 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NV952_RS16740 (3421813) 3421813..3422166 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NV952_RS16750 (3422545) 3422545..3422856 + 312 WP_000409911.1 MGMT family protein -
NV952_RS16755 (3422887) 3422887..3423459 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T254045 WP_001291435.1 NZ_CP102694:3418530-3418748 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT254045 WP_000344800.1 NZ_CP102694:3418130-3418504 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References