Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 889227..889881 Replicon chromosome
Accession NZ_CP102694
Organism Escherichia coli strain GN4554

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag NV952_RS04380 Protein ID WP_000244777.1
Coordinates 889474..889881 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NV952_RS04375 Protein ID WP_000354046.1
Coordinates 889227..889493 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV952_RS04350 (884515) 884515..885258 + 744 Protein_853 SDR family oxidoreductase -
NV952_RS04355 (885315) 885315..886748 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
NV952_RS04360 (886793) 886793..887104 + 312 WP_001679467.1 N(4)-acetylcytidine aminohydrolase -
NV952_RS04365 (887268) 887268..887927 + 660 WP_000250274.1 hemolysin III family protein -
NV952_RS04370 (888004) 888004..888984 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NV952_RS04375 (889227) 889227..889493 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NV952_RS04380 (889474) 889474..889881 + 408 WP_000244777.1 protein YgfX Toxin
NV952_RS04385 (889921) 889921..890442 - 522 WP_001055874.1 flavodoxin FldB -
NV952_RS04390 (890554) 890554..891450 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NV952_RS04395 (891475) 891475..892185 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NV952_RS04400 (892191) 892191..893924 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T254036 WP_000244777.1 NZ_CP102694:889474-889881 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT254036 WP_000354046.1 NZ_CP102694:889227-889493 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References