Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 10945..11588 Replicon plasmid pGN4542-1
Accession NZ_CP102693
Organism Klebsiella pneumoniae strain GN4542

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag NV951_RS25745 Protein ID WP_001044770.1
Coordinates 11172..11588 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag NV951_RS25740 Protein ID WP_001261282.1
Coordinates 10945..11175 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV951_RS25690 (NV951_25685) 6494..6607 + 114 WP_014343462.1 hypothetical protein -
NV951_RS25695 (NV951_25690) 6736..6993 + 258 WP_009310077.1 hypothetical protein -
NV951_RS25700 (NV951_25695) 7051..7830 - 780 WP_023287113.1 site-specific integrase -
NV951_RS25705 (NV951_25700) 7823..7984 - 162 WP_009483881.1 hypothetical protein -
NV951_RS25710 (NV951_25705) 8028..9044 - 1017 WP_009309921.1 hypothetical protein -
NV951_RS25715 (NV951_25710) 9078..9413 - 336 WP_009309920.1 hypothetical protein -
NV951_RS25720 (NV951_25715) 9463..9603 - 141 WP_162898808.1 hypothetical protein -
NV951_RS25725 (NV951_25720) 9832..10137 - 306 WP_009309918.1 type II toxin-antitoxin system toxin CcdB -
NV951_RS25730 (NV951_25725) 10139..10357 - 219 WP_006788213.1 type II toxin-antitoxin system antitoxin CcdA -
NV951_RS25735 (NV951_25730) 10527..10988 - 462 WP_075212430.1 hypothetical protein -
NV951_RS25740 (NV951_25735) 10945..11175 + 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NV951_RS25745 (NV951_25740) 11172..11588 + 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
NV951_RS25750 (NV951_25745) 11662..13224 + 1563 WP_009309907.1 AAA family ATPase -
NV951_RS25755 (NV951_25750) 13209..14231 + 1023 WP_049109415.1 helicase UvrD -
NV951_RS25760 (NV951_25755) 14775..15683 + 909 WP_032425603.1 HNH endonuclease -
NV951_RS25765 (NV951_25760) 15869..16219 - 351 WP_004187110.1 DUF305 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA1 / qacE / sul1 / qnrB4 / blaDHA-1 - 1..178593 178593


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T254030 WP_001044770.1 NZ_CP102693:11172-11588 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT254030 WP_001261282.1 NZ_CP102693:10945-11175 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References