Detailed information of TA system TA025403

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1898647..1899181
• Replicon: chromosome
• Accession: NC_015678
• Organism: Streptococcus parasanguinis ATCC 15912

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F8DHH2
• Locus tag: HMPREF0833_RS08875
• Protein ID: WP_013904578.1
• Coordinates: 1898903..1899181 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I1ZK51
• Locus tag: HMPREF0833_RS08870
• Protein ID: WP_009732165.1
• Coordinates: 1898647..1898910 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMPREF0833_RS08865	1894113..1898507	+	4395	WP_013904576.1	PolC-type DNA polymerase III	-
HMPREF0833_RS08870	1898647..1898910	+	264	WP_009732165.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HMPREF0833_RS08875	1898903..1899181	+	279	WP_013904578.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HMPREF0833_RS10850	1899199..1899348	+	150	WP_003004689.1	hypothetical protein	-
HMPREF0833_RS08885	1899499..1902351	+	2853	WP_041818429.1	AAA family ATPase	-
HMPREF0833_RS08890	1902607..1903848	+	1242	WP_003015886.1	aminopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-86)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 11059.89 Da
• Isoelectric Point: 9.8360

>T25403 WP_013904578.1 NC_015678:1898903-1899181 [Streptococcus parasanguinis ATCC 15912]
VLKIRYHKQFKKDFKLAMKRGLKANLLEEVLNFLVQEKELPVRYRDHQLTNSNHFQGVRECHIQPDWLLVYKVDKDELIL
NLLRTGSHSDLF

Nucleotide

• Length: 279 bp

>T25403 NC_015678:1898903-1899181 [Streptococcus parasanguinis ATCC 15912]
GTGCTTAAGATTCGTTATCATAAACAGTTTAAAAAAGATTTTAAGTTAGCAATGAAGCGTGGTTTAAAGGCAAACTTGTT
AGAAGAAGTTTTGAATTTTCTGGTTCAAGAAAAAGAACTTCCTGTCAGATATCGTGACCATCAACTGACCAACTCCAATC
ATTTCCAAGGTGTTCGGGAGTGTCATATCCAGCCCGATTGGCTTTTGGTTTACAAAGTAGATAAGGATGAATTGATTTTA
AACTTGCTGAGGACAGGAAGTCACAGTGATTTGTTCTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9986.37 Da
• Isoelectric Point: 4.5219

>AT25403 WP_009732165.1 NC_015678:1898647-1898910 [Streptococcus parasanguinis ATCC 15912]
MSKTSMSIRLDSEVKEQAQLVFNHLGMDMTTAINIFLRQAIQYQGLPFDVRLDDHGKLLQVVTDVEQNRNMSQPFESVSD
LMEDLRA

Nucleotide

• Length: 264 bp

>AT25403 NC_015678:1898647-1898910 [Streptococcus parasanguinis ATCC 15912]
ATGTCAAAGACGAGCATGAGTATCCGTTTGGATAGTGAGGTTAAGGAGCAGGCCCAACTGGTGTTCAATCATTTGGGAAT
GGATATGACAACAGCTATCAACATTTTCCTTCGTCAGGCTATTCAATATCAGGGCTTACCTTTTGATGTTCGATTAGATG
ATCATGGGAAGTTGCTCCAAGTAGTAACGGATGTAGAGCAAAATCGGAATATGAGTCAACCCTTTGAATCAGTCTCAGAC
TTGATGGAGGACTTGCGTGCTTAA

Structures

Toxin

• AlphaFold DB: F8DHH2

Antitoxin

• AlphaFold DB: I1ZK51