Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4717219..4717735 Replicon chromosome
Accession NZ_CP102692
Organism Klebsiella pneumoniae strain GN4542

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NV951_RS23065 Protein ID WP_049110203.1
Coordinates 4717219..4717503 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NV951_RS23070 Protein ID WP_002886901.1
Coordinates 4717493..4717735 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV951_RS23040 (NV951_23035) 4712703..4712966 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NV951_RS23045 (NV951_23040) 4713096..4713269 + 174 WP_002886906.1 hypothetical protein -
NV951_RS23050 (NV951_23045) 4713272..4714015 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NV951_RS23055 (NV951_23050) 4714372..4716510 + 2139 WP_049110202.1 anaerobic ribonucleoside-triphosphate reductase -
NV951_RS23060 (NV951_23055) 4716751..4717215 + 465 WP_032418146.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NV951_RS23065 (NV951_23060) 4717219..4717503 - 285 WP_049110203.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NV951_RS23070 (NV951_23065) 4717493..4717735 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NV951_RS23075 (NV951_23070) 4717813..4719723 - 1911 WP_004152270.1 PRD domain-containing protein -
NV951_RS23080 (NV951_23075) 4719746..4720900 - 1155 WP_023159544.1 lactonase family protein -
NV951_RS23085 (NV951_23080) 4720967..4721707 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11093.95 Da        Isoelectric Point: 10.4962

>T254026 WP_049110203.1 NZ_CP102692:c4717503-4717219 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESPRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT254026 WP_002886901.1 NZ_CP102692:c4717735-4717493 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References