Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3967415..3968034 Replicon chromosome
Accession NZ_CP102692
Organism Klebsiella pneumoniae strain GN4542

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NV951_RS19520 Protein ID WP_002892050.1
Coordinates 3967816..3968034 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NV951_RS19515 Protein ID WP_049108832.1
Coordinates 3967415..3967789 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV951_RS19505 (NV951_19500) 3962567..3963760 + 1194 WP_049108834.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NV951_RS19510 (NV951_19505) 3963783..3966929 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
NV951_RS19515 (NV951_19510) 3967415..3967789 + 375 WP_049108832.1 Hha toxicity modulator TomB Antitoxin
NV951_RS19520 (NV951_19515) 3967816..3968034 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NV951_RS19525 (NV951_19520) 3968193..3968759 + 567 WP_002892030.1 maltose O-acetyltransferase -
NV951_RS19530 (NV951_19525) 3968731..3968871 - 141 WP_004147370.1 hypothetical protein -
NV951_RS19535 (NV951_19530) 3968892..3969362 + 471 WP_002892026.1 YlaC family protein -
NV951_RS19540 (NV951_19535) 3969337..3970788 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
NV951_RS19545 (NV951_19540) 3970889..3971587 + 699 WP_004177238.1 GNAT family protein -
NV951_RS19550 (NV951_19545) 3971584..3971724 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
NV951_RS19555 (NV951_19550) 3971724..3971987 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T254024 WP_002892050.1 NZ_CP102692:3967816-3968034 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14354.03 Da        Isoelectric Point: 4.8989

>AT254024 WP_049108832.1 NZ_CP102692:3967415-3967789 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIGQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure

References