Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2589235..2590823 Replicon chromosome
Accession NZ_CP102692
Organism Klebsiella pneumoniae strain GN4542

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NV951_RS12700 Protein ID WP_049109073.1
Coordinates 2589235..2590557 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NV951_RS12705 Protein ID WP_049109072.1
Coordinates 2590557..2590823 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV951_RS12685 (NV951_12690) 2584292..2586793 + 2502 WP_049109074.1 fimbria/pilus outer membrane usher protein -
NV951_RS12690 (NV951_12695) 2586781..2587785 + 1005 WP_016946380.1 fimbrial protein -
NV951_RS12695 (NV951_12700) 2587926..2589218 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NV951_RS12700 (NV951_12705) 2589235..2590557 - 1323 WP_049109073.1 type II toxin-antitoxin system HipA family toxin Toxin
NV951_RS12705 (NV951_12710) 2590557..2590823 - 267 WP_049109072.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NV951_RS12710 (NV951_12715) 2591088..2591414 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NV951_RS12715 (NV951_12720) 2591411..2591911 - 501 WP_040165997.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NV951_RS12720 (NV951_12725) 2591889..2593268 - 1380 WP_049109071.1 nucleobase:cation symporter-2 family protein -
NV951_RS12725 (NV951_12730) 2593614..2594768 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NV951_RS12730 (NV951_12735) 2594749..2595672 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49115.40 Da        Isoelectric Point: 7.5357

>T254023 WP_049109073.1 NZ_CP102692:c2590557-2589235 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPAGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.25 Da        Isoelectric Point: 7.2001

>AT254023 WP_049109072.1 NZ_CP102692:c2590823-2590557 [Klebsiella pneumoniae]
MNSPQIYSPEQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References