Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3121866..3123547 Replicon chromosome
Accession NZ_CP102687
Organism Klebsiella pneumoniae strain GN4539

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NV950_RS15400 Protein ID WP_002885155.1
Coordinates 3121866..3122783 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NV950_RS15405 Protein ID WP_004151732.1
Coordinates 3122789..3123547 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV950_RS15380 (NV950_15375) 3117172..3118692 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NV950_RS15385 (NV950_15380) 3118689..3119687 + 999 WP_002885172.1 ribose ABC transporter permease -
NV950_RS15390 (NV950_15385) 3119718..3120659 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NV950_RS15395 (NV950_15390) 3120734..3121741 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NV950_RS15400 (NV950_15395) 3121866..3122783 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NV950_RS15405 (NV950_15400) 3122789..3123547 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NV950_RS15410 (NV950_15405) 3123633..3124361 - 729 WP_002885152.1 response regulator transcription factor -
NV950_RS15415 (NV950_15410) 3124634..3126781 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NV950_RS15420 (NV950_15415) 3127011..3127697 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T254008 WP_002885155.1 NZ_CP102687:c3122783-3121866 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT254008 WP_004151732.1 NZ_CP102687:c3123547-3122789 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References