Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2965683..2966199 Replicon chromosome
Accession NZ_CP102687
Organism Klebsiella pneumoniae strain GN4539

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NV950_RS14600 Protein ID WP_002886902.1
Coordinates 2965683..2965967 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NV950_RS14605 Protein ID WP_002886901.1
Coordinates 2965957..2966199 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV950_RS14575 (NV950_14570) 2961167..2961475 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
NV950_RS14580 (NV950_14575) 2961560..2961733 + 174 WP_002886906.1 hypothetical protein -
NV950_RS14585 (NV950_14580) 2961736..2962479 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NV950_RS14590 (NV950_14585) 2962836..2964974 + 2139 WP_042943710.1 anaerobic ribonucleoside-triphosphate reductase -
NV950_RS14595 (NV950_14590) 2965215..2965679 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NV950_RS14600 (NV950_14595) 2965683..2965967 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NV950_RS14605 (NV950_14600) 2965957..2966199 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NV950_RS14610 (NV950_14605) 2966277..2968187 - 1911 WP_004152270.1 PRD domain-containing protein -
NV950_RS14615 (NV950_14610) 2968210..2969364 - 1155 WP_002886900.1 lactonase family protein -
NV950_RS14620 (NV950_14615) 2969430..2970170 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T254007 WP_002886902.1 NZ_CP102687:c2965967-2965683 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT254007 WP_002886901.1 NZ_CP102687:c2966199-2965957 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References