Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 926109..927697 Replicon chromosome
Accession NZ_CP102687
Organism Klebsiella pneumoniae strain GN4539

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag NV950_RS04645 Protein ID WP_004199851.1
Coordinates 926109..927431 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NV950_RS04650 Protein ID WP_002904790.1
Coordinates 927431..927697 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV950_RS04630 (NV950_04635) 921174..923675 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
NV950_RS04635 (NV950_04640) 923663..924667 + 1005 WP_004199852.1 fimbrial protein -
NV950_RS04640 (NV950_04645) 924800..926092 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NV950_RS04645 (NV950_04650) 926109..927431 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
NV950_RS04650 (NV950_04655) 927431..927697 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NV950_RS04655 (NV950_04660) 927998..928324 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NV950_RS04660 (NV950_04665) 928321..928821 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NV950_RS04665 (NV950_04670) 928799..930178 - 1380 WP_064449964.1 nucleobase:cation symporter-2 family protein -
NV950_RS04670 (NV950_04675) 930524..931678 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NV950_RS04675 (NV950_04680) 931659..932582 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T254004 WP_004199851.1 NZ_CP102687:c927431-926109 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT254004 WP_002904790.1 NZ_CP102687:c927697-927431 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References